Sökning: "NONMEM"
Visar resultat 1 - 5 av 10 uppsatser innehållade ordet NONMEM.
1. Translation of pharmacometric models from NONMEM to nlmixr2 and RxODE2
Uppsats för yrkesexamina på avancerad nivå, Uppsala universitet/Institutionen för farmaciSammanfattning : The gold standard for pharmacometrics modeling, along with its modeling format, is currently NONMEM. In order to use other software, there is often a manual step of converting a model from one format to another, which is both time-consuming and causes manual errors. LÄS MER
2. Automatic Development of Pharmacokinetic Structural Models
Master-uppsats, Uppsala universitet/Institutionen för farmaciSammanfattning : Introduction: The current development strategy of population pharmacokinetic models is a complex and iterative process that is manually performed by modellers. Such a strategy is time-demanding, subjective, and dependent on the modellers’ experience. LÄS MER
3. Evaluation of Robust Model Building Tools to Improve the Efficiency of Non-linear Mixed Effect Model Building Workflows
Uppsats för yrkesexamina på avancerad nivå, Uppsala universitet/Institutionen för farmaciSammanfattning : Population PK models aim to describe the change in drug concentration over time for a specific population. The populations in population PK modelling often refer to subjects in a clinical trial of a potential drug candidate. LÄS MER
4. Optimized design recommendation for first pharmacokinetic in vivo experiments for new tuberculosis drugs using pharmacometrics modelling and simulation
Uppsats för yrkesexamina på avancerad nivå, Uppsala universitet/Institutionen för farmaciSammanfattning : Tuberculosis, the leading cause of death by a single infection disease caused by bacteria, requires long treatments and the bacteria are prone to develop drug resistance. Therefore, new efficient treatment regiments needs developing, which requires new tools for drug development. LÄS MER
5. Implementation of an automatic quality control of derived data files for NONMEM
Uppsats för yrkesexamina på avancerad nivå, Uppsala universitet/Institutionen för farmaceutisk biovetenskapSammanfattning : A pharmacometric analysis must be based on correct data to be valid. Source clinical data is rarely ready to be modelled as is, but rather needs to be reprogrammed to fit the format required by the pharmacometric modelling software. LÄS MER