Sökning: "PKPD-model"

Hittade 4 uppsatser innehållade ordet PKPD-model.

  1. 1. Towards individualised anaesthesia: A comparison between target-controlled infusion and closed-loop control

    Uppsats för yrkesexamina på avancerad nivå, Lunds universitet/Institutionen för reglerteknik

    Författare :Amanda Gustafsson; [2023]
    Nyckelord :Technology and Engineering;

    Sammanfattning : Individualised healthcare is the future of medicine, due to the so called inter-patient variability. The inter-patient variability involves differences in the drug response between different patients. The effect of a drug can usually be divided into pharmacokinetics (PK) and pharmacodynamics (PD). LÄS MER

  3. 2. Identifiability of pharmacological models from data

    Uppsats för yrkesexamina på avancerad nivå, Lunds universitet/Institutionen för reglerteknik

    Författare :Amina Gojak; [2021]
    Nyckelord :Technology and Engineering;

    Sammanfattning : In order to automate anaesthesia in patients using propofol, closed-loop control systems with models that describe the time course of the drug effects on the body are required, usually being represented by pharmacokinetics and pharmacodynamics(PKPD). This thesis focused on evaluating parameter identifiability for the PK part of the model, using a model proposed by Eleveld et al. LÄS MER

  4. 3. Linking Systems Models of Pharmacology with Behavioural Models of Adherence : A Feasibility Study

    Kandidat-uppsats, KTH/Medicinteknik och hälsosystem

    Författare :Simon Jenner; Dennis Amphan; [2020]
    Nyckelord :Pharmacology; Pharmacokinetics; Pharmacodynamics; PKPD-model; Diabetes; Adherence; Modelling; Feasibility; Farmakologi; Farmakokinetic; Farmakodynamik; PKPD-model; Diabetes; ̊Atlydnad; Modellering; Genomf ̈orbarhet;

    Sammanfattning : Pharmacokinetic (PK)- and pharmacodynamic (PD) modeling are useful tools whenassessing treatment effect. A patient’s adherence can potentially be rate-limiting, since it isthe first process in a chain of processes that determines treatment effect. LÄS MER

  5. 4. PKPD models for colistin and meropenem on a wild-type and a resistant strain of Pseudomonas aeruginosa

    Uppsats för yrkesexamina på avancerad nivå, Institutionen för farmaceutisk biovetenskap

    Författare :Jonathan Lyly; [2011]
    Nyckelord :meropenem; colistin; pseudomonas aeruginosa; models; pharmacometric models; pharmacokinetic models; PKPD;

    Sammanfattning : Resistant bacteria are becoming more and more of a problem but treatment with antibiotics in combination may overcome and prevent resistance development. The combination of meropenem and colistin against Pseudomonas aeruginosa has been proposed as a promising treatment to increase the bactericidal effect and a synergistic effect has been proposed. LÄS MER