Sökning: "PKSim"

Hittade 1 uppsats innehållade ordet PKSim.

  1. 1. Optimized design recommendation for first pharmacokinetic in vivo experiments for new tuberculosis drugs using pharmacometrics modelling and simulation

    Uppsats för yrkesexamina på avancerad nivå, Uppsala universitet/Institutionen för farmaci

    Författare :Albin Leding; [2021]
    Nyckelord :Pharmacokinetics; Pharmacometrics; Pharmacology; population pharmacokinetics; physiologically-based pharmacokinetics; in vitro to in vivo extrapolation; IVIVE; PBPK; PK; popPK; tuberculosis; model informed approach; first in vivo pharmacokinetic experiment; mouse; mice; PKSim; NONMEM; in vitro; in vivo;

    Sammanfattning : Tuberculosis, the leading cause of death by a single infection disease caused by bacteria, requires long treatments and the bacteria are prone to develop drug resistance. Therefore, new efficient treatment regiments needs developing, which requires new tools for drug development. LÄS MER