Sökning: "Peptide"

Visar resultat 1 - 5 av 96 uppsatser innehållade ordet Peptide.

  1. 1. Analysis of hydrogels for immobilisation of hepatocytes (HepG2) in 3D cell culturing systems

    Master-uppsats, Linköpings universitet/Teknisk biologi

    Författare :Elisabeth Westergren; [2018]
    Nyckelord :Hydrogel; Hepatocyte; Tuneable; PEG-peptide; 3D cell culture;

    Sammanfattning : In pharmaceutical development cell cultures are used as in vitro models to evaluate the function of drug candidates. In such research it is vital to have models that resemble the in vivo environment to get reliable results. LÄS MER

  2. 2. NMR Study on the Aggregation Behavior of the Therapeutic Peptide Carbetocin

    Master-uppsats, Lunds universitet/Livsmedelsteknik och nutrition (master)

    Författare :Frida Terne; [2018]
    Nyckelord :Pharmaceutical Technology; läkemedelsteknologi; Chemistry;

    Sammanfattning : Carbetocin is an uncharged cyclic therapeutic peptide with a tendency to aggregate in solution. Aggregation is undesirable since it, for example, can lead to loss of pharmaceutical effects. To gain a better understanding of peptide aggregation, along with a potential to develop better drug formulations, aggregation of carbetocin was studied. LÄS MER

  3. 3. Increased expression of proteins in CHO cells by identification of signal peptides for improved secretion of translated proteins

    Master-uppsats, Linköpings universitet/Teknisk biologi

    Författare :Malin Strannermyr; [2018]
    Nyckelord :Chinese hamster ovary; signal peptide; protein expression; plasmid; library; gene; Fc-fusion; monoclonal antibody; E. coli; flow cytometry; transfection; transformation;

    Sammanfattning : Main purpose of this study was to increase protein expression in Chinese hamster ovary (CHO) cells by improving protein secretion of translated proteins. The goal was to find signal peptides from the screening of signal peptide libraries for improvement of protein secretion using a CHO-cell express selection system. LÄS MER

  4. 4. Antibodies against type II collagen in rheumatoid arthritis. Extended investigations in a large case-control study.

    Master-uppsats, Uppsala universitet/Institutionen för biologisk grundutbildning

    Författare :Eleftheria Pertsinidou; [2018]
    Nyckelord :autoantibodies; rheumatoid arthritis; collagen type II;

    Sammanfattning : Abstract   Introduction Failure in the mechanism of self-tolerance in T or B cells can lead to autoimmunity. One of the autoimmune diseases is rheumatoid arthritis (RA), which is a chronic inflammatory disease of unknown cause and is characterized by systemic inflammation, autoantibodies and joint destruction. LÄS MER

  5. 5. A quantum chemical study of electronic circular dichroism in alanine oligopeptides

    Kandidat-uppsats, KTH/Skolan för teknikvetenskap (SCI)

    Författare :Thomas Agrenius Gustafsson; [2018]
    Nyckelord :;

    Sammanfattning : Circular dichroism (CD) spectroscopy, exploiting the wavelength-dependentdifferential absorption of left- and right-handed circularly polarized light, isa popular method of protein characterization. Theoretically computed CDspectra from quantum mechanical computer models of peptides can widen theapplicability of the method. LÄS MER