Sökning: "Pharmacometrics"

Visar resultat 1 - 5 av 11 uppsatser innehållade ordet Pharmacometrics.

  1. 1. Translation of pharmacometric models from NONMEM to nlmixr2 and RxODE2

    Uppsats för yrkesexamina på avancerad nivå, Uppsala universitet/Institutionen för farmaci

    Författare :Johan Borg; [2023]
    Nyckelord :pharmacy; pharmacokinetics; pharmacodynamics; nlmixr; nlmixr2; rxode; rxode2; conversion; translation; NONMEM; PK; PD; PK PD; model; modeling; modelling;

    Sammanfattning : The gold standard for pharmacometrics modeling, along with its modeling format, is currently NONMEM. In order to use other software, there is often a manual step of converting a model from one format to another, which is both time-consuming and causes manual errors. LÄS MER

  3. 2. Population Pharmacokinetics of Linezolid for Optimization of the Treatment for Multidrug Resistant Tuberculosis

    Uppsats för yrkesexamina på avancerad nivå, Uppsala universitet/Institutionen för farmaci

    Författare :Viktor Hansen; [2022]
    Nyckelord :tuberculosis; drug resistance; pharmacometrics; pharmacokinetics; pop-pk; south africa; non linear mixed effects modelling; nlme;

    Sammanfattning : Tuberculosis is one the leading causes of death globally and was before the COVID-19 pandemic the leading cause of death from a single infectious agent. Developing active tuberculosis is life threatening and therefore is the rise of drug-resistant tuberculosis alarming as this risk causing current treatments to become ineffective. LÄS MER

  4. 3. Infrastructure for quality control of handling of reference data in PBPK projects using PK-Sim

    Uppsats för yrkesexamina på avancerad nivå, Uppsala universitet/Institutionen för farmaci

    Författare :Yasmine Sundelin Tjärnström; [2022]
    Nyckelord :Pharmacometrics; PBPK; R; QC;

    Sammanfattning : PBPK modelling is used in drug development to predict how the drug isaffected by the body. These models are built on physiology and describeprocesses like absorption, distribution, metabolism and excretion.Simulations of these processes can take place in the software PK-Sim forinstance. LÄS MER

  5. 4. Development of artificial neural networks for the prediction of outlying and influential individuals from pharmacokinetic and pharmacodynamic models

    Master-uppsats, Uppsala universitet/Institutionen för farmaci

    Författare :Osama Qutishat; [2022]
    Nyckelord :Machine learning; pharmacometrics; Neural networks; pop-pk;

    Sammanfattning : Nonlinear Mixed effect models are often used to describe population pharmacokinetics (PK) and Pharmacodynamics (PD) and play an important part of drug development both from regulatory and industry point of view. However, they can be time consuming and computationally expensive to develop. LÄS MER

  7. 5. Automatic Development of Pharmacokinetic Structural Models

    Master-uppsats, Uppsala universitet/Institutionen för farmaci

    Författare :Alzahra Hamdan; [2022]
    Nyckelord :pharmacometrics; non-linear mixed effects; modelling; pharmacokinetics; NONMEM; automation; exhaustive algorithm; stepwise algorithm; structural models; inter-individual variability; residual error models; model selection;

    Sammanfattning : Introduction: The current development strategy of population pharmacokinetic models is a complex and iterative process that is manually performed by modellers. Such a strategy is time-demanding, subjective, and dependent on the modellers’ experience. LÄS MER