Sökning: "Pre-clinical studies"

Visar resultat 1 - 5 av 12 uppsatser innehållade orden Pre-clinical studies.

  1. 1. Development of a cell killing adenovirus with a novel cytotoxic transgene

    Master-uppsats, Uppsala universitet/Institutionen för biologisk grundutbildning; Uppsala universitet/Institutionen för immunologi, genetik och patologi

    Författare :Carl Blomqvist; [2023]
    Nyckelord :;

    Sammanfattning : Cancer is among the most common causes of human deaths globally. Because of limitations and adverse effects of conventional cancer treatments, the need for new treatments is imminent. LÄS MER

  3. 2. Design and analysis of pre-clinical experiments using a method combining multiple comparisons and modeling techniques for dose-response studies

    Master-uppsats, Göteborgs universitet/Institutionen för matematiska vetenskaper

    Författare :Avijit Singh; [2021-04-20]
    Nyckelord :pharmacodynamic modeling; dose–response relationship; significance level; multiple comparison procedure; optimal design; MCPMod; dose finding study;

    Sammanfattning : Abstract. Identifying and estimating the dose-response relationship between a compound and a pharmacological endpoint of interest is one of the most important and difficult goals in the preclinical stage of pharmaceutical drug development. LÄS MER

  4. 3. Morphological characterization of neural tissue microstructure using the orientationally-averaged diffusion MRI signal

    Master-uppsats, Linköpings universitet/Avdelningen för medicinsk teknik

    Författare :Iulian Emil Tampu; [2019]
    Nyckelord :MRI; diffusion MRI; orientationally-averaged signal; powder-signal; microstructure;

    Sammanfattning : Diffusion-weighted magnetic resonance imaging (dMRI) is a powerful tool for thecharacterisation of neural tissue microstructural features. The role of neural projectioncurvature on the diffusion signal was recently studied for three temporal regimes of the diffusion pulse sequence in search for a description of the different decay trends in the orientationally-averaged diffusion signal reported in in vivo human studies. LÄS MER

  5. 4. Development of Registration and Fusion Methods for the Jonasson Medical Imaging Center MiniPET-microCT

    Master-uppsats, KTH/Skolan för kemi, bioteknologi och hälsa (CBH)

    Författare :Dimitrios Gkotsoulias; [2018]
    Nyckelord :miniPET; microCT; Medical imaging; Multimodality imaging; Registration; Fusion; Elastix; Mutual Information;

    Sammanfattning : Multimodal image registration is essential when combining functional and structural imaging modalities. Among the most common combinations, numerous methods have been developed for co-registration of CT and PET, typically validated on human size scanners. LÄS MER

  7. 5. A Survey of Commercial Biomolecules, Delimited to Pharmaceuticals and Medical Devices

    Kandidat-uppsats, Uppsala universitet/Institutionen för teknikvetenskaper

    Författare :Alberto Martinez; Nadia Mohammadi; Markus Holowacz; Annika Krans; Camilla Wallén; [2017]
    Nyckelord :Biologics;

    Sammanfattning : Biologics — biomolecule-based therapeutics — are predicted to become the next generation of therapeutical drugs. The pharmaceutical industry is investing a great amount of money into research in this medical field, which shows the importance and the need of analyses regarding biological drugs. LÄS MER