Sökning: "Proteolysis targeting chimera PROTAC"

Hittade 2 uppsatser innehållade orden Proteolysis targeting chimera PROTAC.

1. 1. Inhibitory effect on the proteasome regulatory subunit, RPN11/POH1, with the use of Capzimin-PROTAC to trigger apoptosis in cancer cells

   Kandidat-uppsats, Linköpings universitet/Kemi

   Författare :Andreas Holmqvist; [2020]
   Nyckelord :Proteolysis targeting chimera PROTAC ; Cancer therapeutics; Ubiquitin proteasome system UPS ; Cancer; Chemotherapy; Proteasome inhibitor; Capzimin;

   Sammanfattning : Most patients diagnosed with cancer will receive systematic chemotherapy at some point during their illness, which almost always cause severe side effects for the patients such as, anemia, nausea and vomiting. The problems with today’s chemotherapy is not only that it cause severe side effects, but also that the cancer may develop resistance to the therapy, which is why the development of a new type of therapeutic agent is in dire need. LÄS MER

3. 2. Chemical design, synthesis and biological evaluation of novel proteolysis targeting chimeras (PROTACs) for the degradation of NUDT5

   Uppsats för yrkesexamina på avancerad nivå, Uppsala universitet/Preparativ läkemedelskemi

   Författare :Gabriel Tidestav; [2020]
   Nyckelord :protac; proteolysis targeting chimera; targetted protein degradation; nudt5; breast cancer; e3 ligase; ligands; vhl; crbn; theophylline;

   Sammanfattning : Proteolysis targeting chimeras (PROTACs) represent a new modality in drug design. They are bifunctional molecules; with one end, they bind to a protein of interest, and with the other end, they bind to endogenous E3 ligases. LÄS MER