Sökning: "Regulatory gene network"

Visar resultat 1 - 5 av 12 uppsatser innehållade orden Regulatory gene network.

  1. 1. Patterning of the neural tube: A 3D computational modelling approach

    Master-uppsats, Lunds universitet/Institutionen för astronomi och teoretisk fysik; Lunds universitet/Beräkningsbiologi och biologisk fysik

    Författare :Ariane Ernst; [2019]
    Nyckelord :gene regulatory networks; neural tube patterning; patterning of the neural tube; dopaminergic neurons; parkinson s disease; computational modelling; stem cell; GRN; Biology and Life Sciences; Physics and Astronomy;

    Sammanfattning : Neurodegenerative diseases such as Parkinson’s can be treated with stem-cell derived specialized neurons. In order to achieve precise directed neural differentiation in vitro we need to understand the gene regulatory mechanisms behind in vivo neural tube patterning. LÄS MER

  2. 2. Identifying Cell Reprogramming Roadblocks by Modelling Induced Pluripotency with Boolean Networks and Dynamical Systems

    Master-uppsats, Lunds universitet/Institutionen för astronomi och teoretisk fysik; Lunds universitet/Beräkningsbiologi och biologisk fysik

    Författare :Johannes Isaksson; [2018]
    Nyckelord :Stem cells; pluripotency; pluripotent; reprogramming; iPS; induced pluripotency; Boolean; dynamical systems; network.; Medicine and Health Sciences;

    Sammanfattning : The generation of induced pluripotent stem (iPS) cells from differentiated cells is a process of great scientific interest due to the medical potential of such cells. This process (called 'reprogramming' of cells) is however notoriously inefficient and still not very well understood. LÄS MER

  3. 3. Robust Community Predictions of Hubs in Gene Regulatory Networks

    Master-uppsats, Linköpings universitet/Bioinformatik

    Författare :Julia Åkesson; [2018]
    Nyckelord :Biological systems; Biological networks; Network inference; Gene regulatory networks; Hubs; Master regulators; Community predictions; Bioinformatics;

    Sammanfattning : Many diseases, such as cardiovascular diseases, cancer and diabetes, originate from several malfunctions in biological systems. The human body is regulated by a wide range of biological systems, composed of biological entities interacting in complex networks, responsible for carrying out specific functions. LÄS MER

  4. 4. Modelling conversion of adult skin cells to neurons

    Master-uppsats, Lunds universitet/Institutionen för astronomi och teoretisk fysik; Lunds universitet/Beräkningsbiologi och biologisk fysik

    Författare :Viktor Drugge; [2018]
    Nyckelord :Human adult fibroblast; Neuron; Neural conversion; Transdifferentiation; Direct reprogramming; Direct lineage conversion; Simulation; Regulatory gene network; Gene network topology; Gene circuit; Gene dynamics; Physics and Astronomy;

    Sammanfattning : Scientists are now able to directly convert one somatic cell type into another using a procedure known as direct lineage reprogramming or transdifferentiation. In this procedure, transcription factors which are important for initiating a rewriting of the gene expressions are introduced in the cell. LÄS MER

  5. 5. A Mixture-of-Experts Approach for Gene Regulatory Network Inference

    Master-uppsats, Blekinge Tekniska Högskola/Institutionen för datalogi och datorsystemteknik

    Författare :Borong Shao; [2014]
    Nyckelord :GRN inference; Ensemble learning; Mixture-of-Experts; network motif analysis;

    Sammanfattning : Context. Gene regulatory network (GRN) inference is an important and challenging problem in bioinformatics. A variety of machine learning algorithms have been applied to increase the GRN inference accuracy. Ensemble learning methods are shown to yield a higher inference accuracy than individual algorithms. LÄS MER