Sökning: "Serial crystallography"

Hittade 5 uppsatser innehållade orden Serial crystallography.

1. 1. A Machine Learning Approach on Analysis of Emission Spectra for Application in XFEL Experiments

   Uppsats för yrkesexamina på avancerad nivå, Uppsala universitet/Institutionen för fysik och astronomi

   Författare :Harald Agelii; [2023]
   Nyckelord :Structural biology; Machine learning; Neural networks; emission spectrum; XFEL; X-ray free electron laser; SFX; Serial femtosecond X-ray crystallography; Proteins; Diagnostics;

   Sammanfattning : In this thesis we investigate two potential applications of machine learning in the context of X-ray imaging and spectroscopy of biological samples, particularly such using X-ray free electron lasers (XFEL). We first investigate the possibility of using an emission spectrum, recorded from a sample after being probed by an incident X-ray, as a diagnostic tool. LÄS MER

3. 2. Acoustic Focusing of Lysozyme Crystals

   Master-uppsats, KTH/Tillämpad fysik

   Författare :Måns Junestrand; [2023]
   Nyckelord :Protein Crystals; Lysozyme Crystals; Ultrasound; Acoustic Focusing; SFX; Biomedical Physics; Proteinkristaller; Ultraljud; Lysozymkristaller; Akustisk fokusering; SFX; Biomedicinsk fysik;

   Sammanfattning : Acoustic focusing of microscale protein crystals with acoustophoresis technology could reduce clogs during experiments with the scientific technique serial femtosecond x-ray crystallography (SFX). SFX determines molecular structures of proteins, these structures are valuable in drug discovery and fundamental biomedical research. LÄS MER

4. 3. Optical Detector for Microfluidics

   Magister-uppsats, Högskolan i Halmstad/Akademin för informationsteknologi

   Författare :Carlos Gómez Jiménez; Jaime Gómez Jiménez; [2022]
   Nyckelord :Serial crystallography; Microfluidic device; Optical detector; Particle counting;

   Sammanfattning : This project arose from the need to filter the sampled data and eliminate non-useful information in Serial Crystallography in Microfluidic Device (MFD)by using a portable optical detector placed around the channel. By testing sixteen different configurations, always using an LED as a source and a photodiode as a light sensor, changes in the channel due to the passage of air bubbles were detected. LÄS MER

5. 4. The Importance of Radiation Damage for Molecular Reconstruction from FEL Diffraction Experiments

   Uppsats för yrkesexamina på avancerad nivå, Uppsala universitet/Molekyl- och kondenserade materiens fysik

   Författare :Nicklas Bjärnhall Prytz; [2018]
   Nyckelord :Radiation damage; SFX; XFEL; Diffraction; Protein; Crystallography;

   Sammanfattning : Serial Femtosecond X-ray crystallography (SFX) is a rapidly growing experimental technique by which the structure of a crystalline sample may be determined. The X- rays arrive at the sample in pulse trains of the order of femtoseconds. LÄS MER

7. 5. Single-molecule X-ray free-electron laser imaging : Interconnecting sample orientation with explosion data

   Uppsats för yrkesexamina på avancerad nivå, Uppsala universitet/Institutionen för biologisk grundutbildning

   Författare :Christofer Östlin; [2014]
   Nyckelord :X-ray; free-electron laser; XFEL; diffraction analysis; structure determination; nanocrystal; molecular dynamics; GROMACS; biomolecular imaging; ubiquitin; trajectory; explosion;

   Sammanfattning : X-ray crystallography has been around for 100 years and remains the preferred technique for solving molecular structures today. However, its reliance on the production of sufficiently large crystals is limiting, considering that crystallization cannot be achieved for a vast range of biomolecules. LÄS MER