Sökning: "Single-cell analysis"

Visar resultat 1 - 5 av 21 uppsatser innehållade orden Single-cell analysis.

  1. 1. The role of RFX-target genes in neurodevelopmental and psychiatric disorders

    Master-uppsats, Uppsala universitet/Institutionen för biologisk grundutbildning

    Författare :Abhishekapriya Ganesan; [2021]
    Nyckelord :;

    Sammanfattning : Neurodevelopmental disorders such as autism spectrum disorder (ASD) and psychiatric disorders, for example, schizophrenia (SCZ) represent a large spectrum of disorders that manifest through cognitive and behavioural problems. ASD and SCZ are both highly heritable, and some phenotypic similarities between ASD and SCZ have sparked an interest in understanding their genetic commonalities. LÄS MER

  2. 2. Machine learning methods for seasonal allergic rhinitis studies

    Master-uppsats, Linköpings universitet/Statistik och maskininlärning

    Författare :Zijie Feng; [2021]
    Nyckelord :Machine learning; Seasonal allergic rhinitis; Random forest; Partial least squares discriminant analysis; Bootstrap; Cubic smoothing splines; Single-cell RNA sequencing;

    Sammanfattning : Seasonal allergic rhinitis (SAR) is a disease caused by allergens from both environmental and genetic factors. Some researchers have studied the SAR based on traditional genetic methodologies. As technology develops, a new technique called single-cell RNA sequencing (scRNA-seq) is developed, which can generate high-dimension data. LÄS MER

  3. 3. Investigating the protein-protein Interaction between Aquaporin 4 & Calmodulin

    Magister-uppsats, Lunds universitet/Kemiska institutionen

    Författare :Zahraa Majhool; [2020]
    Nyckelord :aquaporin4 protein-protein; interaction calmodulin ; biochemistry; molecular biology; biokemi; molekylärbiologi; Chemistry;

    Sammanfattning : Around 60 million people around the world are struggling with a traumatic brain or spinal cord injury. The swelling of the brain or spinal cord happen when the water content in the CNS increase due, infection, tumor growth or brain edema. LÄS MER

  4. 4. Analysis of single cell RNA seq data to identify markers for subtyping of non-small cell lung cancer

    Magister-uppsats, Högskolan i Skövde/Institutionen för biovetenskap

    Författare :Veena K. Reddy; [2020]
    Nyckelord :;

    Sammanfattning : Single cell RNA technology is a recent technical advancement used to understand the cancertumorgenicity at single cell resolution. In this study we have analyzed the scRNA data from thenon-small cell lung cancer (NSCLC) dataset to facilitate the early identification of NSCLCsubtypes namely, squamous cell carcinoma (SCC) and adenocarcinoma (AC). LÄS MER

  5. 5. THE TRANSCRIPTIONAL LANDSCAPE OF B CELLS UPON MUCOSAL HEALING IN EXPERIMENTAL COLITIS : A SINGLE CELL TRANSCRIPTOMICS ANALYSIS

    Master-uppsats, Uppsala universitet/Institutionen för biologisk grundutbildning

    Författare :Claudio Novella Rausell; [2020]
    Nyckelord :IBD; scRNA-seq; Machine Learning; Single Cell; Statistics; Dimensionality Reduction; UMAP;

    Sammanfattning : Upon damage of the intestinal barrier, a complex interaction between the immune system and the epithelium is required to promote mucosal healing. However, which cell type and how the immune system orchestrates changes in the tissue transcriptomic landscape to eventually modulate mucosal healing is yet to be investigated. LÄS MER