Sökning: "Smad2"
Hittade 4 uppsatser innehållade ordet Smad2.
1. TGFβ2 may phosphorylate SMAD2, SMAD3, ERK1/2, JNK and p38 in human umbilical vein endothelial cells
Master-uppsats, Örebro universitet/Institutionen för hälsovetenskaperSammanfattning : Introduction The dysfunction of human endothelial cells caused by exposure to inflammatory mediators, such as TGFβ, leads to development of diseases, such as atherosclerotic diseases. TGFβ mediated endothelial dysfunction may involve MMP-9. MMP9 is highly expressed in atherosclerotic plaques. LÄS MER
2. 1,25(OH)2D3 and Initial Regulation of Smad2/3 Activity in PC-3 Prostate Cancer Cells
Magister-uppsats, Institutionen för vård och naturSammanfattning : The vitamin D metabolite 1,25(OH)2D3 has long been known to inhibit growth of prostate cancer cells and this mainly through a VDR-mediated pathway controlling target gene expression, resulting in cell cycle arrest, apoptosis and differentiation. Another major way in which 1,25(OH)2D3 inhibits cell growth in prostate cancer is via membrane-initiated steroid signalling, which triggers activation of signal cascades upon steroid binding to a receptor complex, leading to induction of genes regulating cell growth, proliferation and apoptosis. LÄS MER
3. Effects of 1,25(OH)2D3 on Smad2 Activity in PC-3 Prostate Cancer Cells
L3-uppsats, Institutionen för vård och naturSammanfattning : The vitamin D metabolite 1,25(OH)2D3 has long been known to inhibit growth of prostate cancer cells and this mainly through a VDR-mediated pathway controlling target gene expression, resulting in cell cycle arrest, apoptosis and differentiation. Another major way inwhich 1,25(OH)2D3 inhibits cell growth in prostate cancer is via membrane-initiated steroid signalling, which triggers activation of signal cascades upon steroid binding to a receptor complex, leading to induction of genes regulating cell growth, proliferation and apoptosis. LÄS MER
4. 1,25(OH)2D3 Initially Reduces TGFβ Activity in PC-3 Prostate Cancer Cells
Magister-uppsats, Institutionen för vård och naturSammanfattning : The vitamin D metabolite 1,25(OH)2D3 has long been known to inhibit growth of prostate cancer cells and this mainly through a VDR-mediated pathway controlling target gene expression, resulting in cell cycle arrest, apoptosis and differentiation. Another major way in which 1,25(OH)2D3 inhibits cell growth in prostate cancer is via membrane-initiated steroid signalling, which triggers activation of signal cascades upon steroid binding to a receptor complex, leading to induction of genes regulating cell growth, proliferation and apoptosis. LÄS MER