Sökning: "Solid-phase synthesis"

Visar resultat 1 - 5 av 17 uppsatser innehållade orden Solid-phase synthesis.

  1. 1. Development of a PNA-drug conjugate for pretargeted delivery of cytotoxic drugs

    Uppsats för yrkesexamina på avancerad nivå, Uppsala universitet/Theranostics

    Författare :Astrid Haraldsson; [2023]
    Nyckelord :PNA; pretargeting; cancer therapy; cytotoxic payload;

    Sammanfattning : One of the major challenges in cancer treatment is delivering high enough doses of active substance specifically to cancer cells without accumulation in healthy organs. Pretargeting has emerged as a potential solution, where the delivery of a cancer recognizing (primary) agent and a cancer killing (secondary) agent are separated. LÄS MER

  3. 2. A novel approach for functionalising and separating Tröger's Base Analogues

    Master-uppsats, Lunds universitet/Centrum för analys och syntes

    Författare :Emil Jakobsson; [2023]
    Nyckelord :Tröger s Base; Synthesis; Chromatography; Supramolecular chemistry; Diastereomers; Organic chemistry; Chemistry;

    Sammanfattning : Tröger’s Base (TB) is a bicyclic compound containing a methanodiazocine group between two aromatic rings. The methylene bridge forces the molecule to have a bent formation; thus, the aromatic rings are close to 90 degrees relative to each other, resulting in a rigid concave aromatic cavity. LÄS MER

  4. 3. Greening peptide chemistry by using NBP as solvent for SPPS

    Master-uppsats, Lunds universitet/Centrum för analys och syntes

    Författare :Andrea Ölander; [2022]
    Nyckelord :SPPS; Green chemistry; Peptide Synthesis; Organic chemistry; Organisk kemi; Chemistry;

    Sammanfattning : The preferred method for synthesising therapeutic peptides today is by Solid-Phase Peptide Synthesis (SPPS). SPPS is a wasteful process, where the main component of the waste is hazardous solvents, i.e., N,N-dimethylformamide (DMF), N-methylpyrrolidone (NMP) or dichloromethane (DCM). LÄS MER

  5. 4. Evaluation of the immunogenicity of SARS-CoV-2 B cell epitopes

    Master-uppsats, Uppsala universitet/Institutionen för farmaceutisk biovetenskap

    Författare :Sofia Hogander; [2022]
    Nyckelord :SARS-CoV-2; peptide vaccine; B cell epitope; ELISA; solid phase peptide synthesis;

    Sammanfattning : Background: The COVID-19 pandemic is caused by the SARS-CoV-2 virus, which enter the host cells through interactions between the receptor-binding domain (RBD) on the S-protein and the ACE-2 receptor on the host cell. A novel type of vaccine strategy is peptide vaccines, with great potential as a faster and more selective approach to conventional vaccine development. LÄS MER

  7. 5. Streamlining the manufacturing of biotherapeutics : SPPS vs. Recombinant protein production

    Kandidat-uppsats, Uppsala universitet/Institutionen för biologisk grundutbildning

    Författare :Matilda Carlson; Alma Hansen; Tyra Levin; Moa Rick; Frida Tallqvist; Malin Tiefensee; [2021]
    Nyckelord :;

    Sammanfattning : In this paper we have researched two methods for peptide synthesis; solid phase peptide synthesis (SPPS) and recombinant protein production, hereafter called recombinant production. The goal was to create a decision support that can be of use when choosing a production method for a given peptide. LÄS MER