Sökning: "Srinidhi Varadharajan"

Hittade 1 uppsats innehållade orden Srinidhi Varadharajan.

  1. 1. Building predictive unbound brain-to-plasma concentration ratio (Kp,uu,brain) models

    Master-uppsats, Lunds universitet/Examensarbeten i bioinformatik

    Författare :Srinidhi Varadharajan; [2014]
    Nyckelord :Biology and Life Sciences;

    Sammanfattning : Abstract The blood-brain barrier (BBB) constitutes a dynamic membrane primarily evolved to protect the brain from exposure to harmful xenobiotics. The distribution of synthesized drugs across the blood-brain barrier (BBB) is a vital parameter to consider in drug discovery projects involving a central nervous system (CNS) target, since the molecules should be capable of crossing the major hurdle, BBB. LÄS MER