Sökning: "Subtilisin"

Hittade 4 uppsatser innehållade ordet Subtilisin.

  1. 1. Production and analysis of novel disulfide variants of Subtilisin Carlsberg

    Master-uppsats, Linköpings universitet/Kemi

    Författare :Anton Elfstrand; [2023]
    Nyckelord :Subtilisin Carlsberg; Disulfide; Protein Engineering; Kinetic Stability;

    Sammanfattning : Protein engineering has been used to alter the stability of proteins for several decades withmuch success, one approach being to introduce two cysteine residues that together form adisulfide bridge. The disulfide bridge can increase the Gibbs free energy of the transitionstate, thus increasing energy difference between the folded state and the unfolding transitionstate, leading to increased kinetic stability of the protein. LÄS MER

  3. 2. Methods for production of recombinant enzymes for collagen degradation

    Master-uppsats, Lunds universitet/Tillämpad biokemi; Lunds universitet/Beräkningskemi

    Författare :Tea Eriksson; Elin Su; [2020]
    Nyckelord :Collagenase; Subtilisin; Collagen; Enzymatic hydrolysis; Enzymes; Collagen degradation; Enzyme production; Cloning; Gene optimization; Protein expression; Technology and Engineering;

    Sammanfattning : In this thesis eight enzymes have been identified with documented ability to degrade collagen or its hydrolyzed products. Collagen can be found in skin, bones, and connective tissue. Hydrolyzed collagen peptides are utilized in food, disease treatment, skincare and training supplements. LÄS MER

  4. 3. Evolokumabs effekt och kostnadseffektivitet hos patienter utan familjär kolesterolemi.

    Kandidat-uppsats, Linnéuniversitetet/Institutionen för kemi och biomedicin (KOB)

    Författare :Tor Molin; [2019]
    Nyckelord :Evolocumab; PCSK9; Atherosclerosis; Evolokumab; PCSK9; Ateroskleros;

    Sammanfattning : Atherosclerosis is the underlying cause for many serious cardiovascular diseases which causes over 50 % of all deaths in Sweden. Atherosclerotic plaque builds up in the vessel walls over decades that will eventually lead to a complete block of an artery or cause thrombosis when the plaque ruptures, this leads to myocardial infarction and stroke. LÄS MER

  5. 4. Mipomersen, an apolipoprotein B synthesis inhibitor : A literature study analyzing efficacy and safety when used for treating patients with familial hypercholesterolemia

    Kandidat-uppsats, Linnéuniversitetet/Institutionen för kemi och biomedicin (KOB)

    Författare :Cathrine Fernando; [2019]
    Nyckelord :mipomersen; familial hypercholesterolemia;

    Sammanfattning : Familial hypercholesterolemia is a genetic disease affecting about 10 million people around the world. Those who carry the disease have a very high risk of developing cardiovascular diseases and commonly encounter myocardial infarction at the early age of 40. Therefore, a diagnosis and immediate treatment are very important for these patients. LÄS MER