Sökning: "Surface plasmon resonance SPR"

Visar resultat 1 - 5 av 21 uppsatser innehållade orden Surface plasmon resonance SPR.

  1. 1. Development of a PNA-drug conjugate for pretargeted delivery of cytotoxic drugs

    Uppsats för yrkesexamina på avancerad nivå, Uppsala universitet/Theranostics

    Författare :Astrid Haraldsson; [2023]
    Nyckelord :PNA; pretargeting; cancer therapy; cytotoxic payload;

    Sammanfattning : One of the major challenges in cancer treatment is delivering high enough doses of active substance specifically to cancer cells without accumulation in healthy organs. Pretargeting has emerged as a potential solution, where the delivery of a cancer recognizing (primary) agent and a cancer killing (secondary) agent are separated. LÄS MER

  3. 2. BIOMIMETIC SENSORS FOR RAPID AND SENSITIVE SARS-CoV-2 DETECTION

    Master-uppsats, Malmö universitet/Fakulteten för hälsa och samhälle (HS)

    Författare :Maryam Hmouda; [2022]
    Nyckelord :;

    Sammanfattning : In the last two years, the COVID-19 pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has impacted the entire world. SARS-CoV-2 detection methods include Polymerase Chain Reaction (PCR), which is expensive, and Rapid Antigen Test, which is not highly sensitive. LÄS MER

  4. 3. Affibody phage display selections for lipid nanoparticle and affibody-mediated transient CAR T-cell therapy

    Master-uppsats, KTH/Proteinvetenskap

    Författare :Tasnim Yasin Idris; [2022]
    Nyckelord :affibody; phage display; in vitro selection; CD5; CD8; CD19; CAR T-cell therapy.;

    Sammanfattning : CAR T-cellbehandling är en immunterapi som har visat lovande resultat vid behandling av cancer. Trots det riktade immunsvaret som kan uppnås, betonar komplexiteten i tillverkningsprocessen och behandlingsproceduren det utrymme somm finns för förbättringar. LÄS MER

  5. 4. Production and Evaluation of a Bombesin Analogue Conjugated to the Albumin-Binding Domain and DOTA for Prostate Cancer Radiotherapy

    Master-uppsats, KTH/Proteinvetenskap

    Författare :Fredrika Landmark; [2021]
    Nyckelord :bombesin; prostate cancer; radiotherapy; human serum albumin; half-life extension; bombesin; prostatacancer; radioterapi; humant serumalbumin; halveringstidsförlängning;

    Sammanfattning : Prostate cancer is one of the most common types of cancer worldwide and claims hundreds of thousands of lives annually. Currently the most common treatment for prostate cancer is external beam radiotherapy, however, this treatment comes with serious side effects since it lacks selectivity for the cancer cells. LÄS MER

  7. 5. Biophysical characterization of and screening for binders and potentiator compounds that modulate the binding of PDZ domains to the C-terminal peptide motifs of target proteins

    Master-uppsats, KTH/Proteinvetenskap

    Författare :Carl Olsson; [2021]
    Nyckelord :Post synaptic density protein 95; PDZ-domains; N-methyl-D-aspartate receptor; NMDAR hypofunctional hypothesis; GluN2b; Differential scanning fluorimetry; Surface plasmon resonance; Fragment based drug design; Assay development;

    Sammanfattning : The N-methyl-D-aspartate receptor (NMDAR) hypofunctional hypothesis is believed to explain one of the contributing factors to schizophrenia. This hypothesis suggests the dysregulation of NMDAR, a protein responsible for receiving signals from the synapses between neurons, is the cause of some of the symptoms seen in schizophrenia. LÄS MER