Sökning: "Sylvia Ros"

Hittade 1 uppsats innehållade orden Sylvia Ros.

  1. 1. A1M, Hb and tryptophan metabolism in R6/2 mouse model of Huntington’s disease

    Master-uppsats, Lunds universitet/Läkarutbildningen

    Författare :Sylvia Karlberg; [2012]
    Nyckelord :Huntington s Disease; kynurenine; tryptophan metabolism; A1M; Alpha-1-microglobulin; hemoglobin; neurology; neurobiology; neurochemistry; immune system; Medicine and Health Sciences;

    Sammanfattning : Neurotoxic metabolites generated from tryptophan metabolism are increasingly regarded as a pathogenic mechanism in neurological and psychiatric disease including Huntington’s disease (HD). Specifically, the tryptophan-derived neurotoxin 3-hydroxykynurenine (3-HK) accumulates in HD brain and is capable of damaging neurons through excessive ROS-production and oxidative stress. LÄS MER