Sökning: "Targeted proteomics"

Visar resultat 1 - 5 av 8 uppsatser innehållade orden Targeted proteomics.

1. 1. Evaluating targeted combination therapies in EGFR wild-type non-small-cell lung cancer using mass spectrometry-based proteomics

   Master-uppsats, Lunds universitet/Institutionen för immunteknologi

   Författare :Johan Thorsson; [2023]
   Nyckelord :Biology and Life Sciences;

   Sammanfattning : Survival for non-small cell lung cancer (NSCLC) patients has been significantly improved by epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) in patients with EGFR mutations. However, certain subpopulations of NSCLC patients with EGFR wild-type (wt) status have been shown to also respond to EGFR-TKIs. LÄS MER

3. 2. Biologically informed neural network for subphenotype classification in septic AKI

   Master-uppsats, Lunds universitet/Avdelningen för Biomedicinsk teknik

   Författare :Erik Hartman; [2022]
   Nyckelord :Machine learning; neural networks; proteomics; sepsis; AKI; Technology and Engineering;

   Sammanfattning : Sepsis is a life threatening condition where the body’s reaction to an infection results in a dysregulated immune response - ultimately causing damage to tissues and organs. The syndrome is diverse, both in underlying biology, disease manifestation and severity, and is therefore divided into endotypes and further into subphenotypes. LÄS MER

4. 3. Prediction of Ranking of Chromatographic Retention Times using a Convolutional Network

   Master-uppsats, KTH/Skolan för elektroteknik och datavetenskap (EECS)

   Författare :Daniel Kruczek; [2018]
   Nyckelord :Shotgun proteomics; retention time; retention time prediction; neural networks; convolutional neural networks;

   Sammanfattning : In shotgun proteomics, the liquid chromatography step is used to separate peptides in order to analyze as few as possible at the same time in the mass spectrometry step. Each peptide has a retention time, that is how long it takes to pass through the chromatography column. LÄS MER

5. 4. Investigating causative genes for atherosclerosis and coronary heart disease in a zebrafish model system using CRISPR-Cas9technology

   Master-uppsats, Uppsala universitet/Institutionen för biologisk grundutbildning

   Författare :Shreya Pundir; [2017]
   Nyckelord :Atherosclerosis; Coronary Artery Disease; zebrafish; CRISPR-Cas9;

   Sammanfattning : Coronary artery disease (CAD) is the major cause of death worldwide and atherosclerosis is the major cause of CAD. An unpublished, high-throughput proteomics approach recently identified two of these proteins – Vascular Endothelial Growth Factor A (VEGFA) and Matrix metalloproteinases (MMP12) that were associated with incident CAD in Uppsala-based samples from the prospective investigation of the vascular in Uppsala Seniors (PIVUS) and the Uppsala longitudinal study of adult men studies (ULSAM). LÄS MER

7. 5. Development of an assay to monitor the role of Serum Amyloid P-component in Alzheimer's Disease

   Master-uppsats, Uppsala universitet/Institutionen för biologisk grundutbildning

   Författare :Eleni Gkanatsiou; [2016]
   Nyckelord :Alzheimer s Disease; Biomarker development; mass spectrometry; quantitative proteomics; Serum Amyloid P-component; immunoprecipitation;

   Sammanfattning : Alzheimer’s Disease is the most common form of dementia, affecting 48 million people worldwide. Despite this fact, only 45% of the patients have received the diagnose. The reason behind this is the fact that the cause of the disease is still unclear. LÄS MER