Sökning: "Tissue Visualization"

Visar resultat 1 - 5 av 23 uppsatser innehållade orden Tissue Visualization.

  1. 1. Virtual H&E Staining Using PLS Microscopy and Neural Networks

    Master-uppsats, Lunds universitet/Matematik LTH

    Författare :Sally Vizins; Hanna Råhnängen; [2024]
    Nyckelord :Deep learning; Virtual staining; Skin tissue; Hematoxylin Eosin; H E; Pathology; Carcinoma; Point light source illumination; Neural Networks; GANs; Generative adversarial networks; CNNs; Convolutional neural networks; Relativistic generative adversarial network; Unet; Digital microscopy; Attention-Unet; Dense-Unet; Mathematics and Statistics;

    Sammanfattning : Histopathological examination, crucial in diagnosing diseases such as cancer, traditionally relies on time- and resource-consuming, poorly standardized chemical staining for tissue visualization. This thesis presents a novel digital alternative using generative neural networks and a point light source (PLS) microscope to transform unstained skin tissue images into their stained counterparts. LÄS MER

  3. 2. Quantification of Pharmaceuticals at the sub-cellular level using the NanoSIMS

    Uppsats för yrkesexamina på avancerad nivå, Uppsala universitet/Analytisk kemi

    Författare :Maryam Dost; [2024]
    Nyckelord :Mass spectroscopy imaging; AstraZeneca; Nanosims; Therapeutics; pharmacokinetics; pharmacodynamics; Quantitative Visualization; calibration curve; RSF; pharmacology; Data Analysis; Chemistry; Quantification; isotopes; Pharmaceuticals; subcellular; drug; drug target; nucleotide; biodistribution; Bioanalytical electrochemistry; spectroscopy; mass spectrometry; analytical separations; Analytical Chemistry; ROI; Bioanalytical Chemistry; Masspektroskopi avbildning; AstraZeneca; Nanosims; Terapeutik; farmakokinetik; farmakodynamik; Kvantitativ visualisering; kalibreringskurva; RSF; farmakologi; Dataanalys; Kemi; Kvantifiering; isotoper; Läkemedel; subcellulär; läkemedel; läkemedelsmål; bioskopisk elektrofördelning; nukleotid; bioskopisk bioskopisk distribution; masspektrometri; analytiska separationer; analytisk kemi; bioanalytisk kemi;

    Sammanfattning : Mass spectroscopy imaging (MSI) has become a vital tool in modern research due to its ability to visualize the spatial distribution of molecules within tissue samples. The collaboration between researchers at AZ, the University of Gothenburg, and Chalmers University of Technology using the NanoSIMS instrument and MSI-SIMS technology has opened up new avenues of exploration in pharmaceutical development, particularly in examining drugs and metabolites at sub-cellular levels. LÄS MER

  4. 3. Ovary spheroid formation and quality assessment using two different protocols

    Master-uppsats, KTH/Proteinvetenskap

    Författare :Nikki Wallius Hiltunen; [2023]
    Nyckelord :ovary; fertility; spheroid; Biosilk™; three-layer gradient system; äggstock; fertilitet; sfäroid; Biosilk™; trelagers gradientsystem;

    Sammanfattning : Redan innan födseln fastställs kvinnors fertilitet, som karakteriseras av ett begränsat antal äggblåsor, så kallade folliklar. Beståndet av folliklar minskar naturligt med åldern, samtidigt som kvinnors fertilitet beror på deras steroid- och äggproduktion. LÄS MER

  5. 4. Visualizing osteonecrosis of jaws through neutrophil elastase : [11C]NES novel PET tracer

    Uppsats för yrkesexamina på grundnivå, Uppsala universitet/Institutionen för läkemedelskemi

    Författare :Amanda Dannberg; Theodora Martinez; [2023]
    Nyckelord :[11C]NES; HNC; MRONJ; neutrophil granulocytes; ORN; osteonecrosis; PET CT; radiation therapy; [11C]NES; huvud- och halscancer; MRONJ; neutrofila granulocyter; ORN; osteonekros; PET CT; strålbehandling;

    Sammanfattning : Radiation and medical drugs are used to fight head and neck cancer, but unfortunately in some cases these treatments cause development of other diseases and injuries. Osteoradionecrosis (ORN) and medical-related osteonecrosis of the jaw (MRONJ) are dreaded late complications in jaws from radiation therapy and medical drugs and cause great suffering to those affected. LÄS MER

  7. 5. Implementation and Visualization of Importance sampling in Deep learning

    Master-uppsats, Linköpings universitet/Medie- och Informationsteknik; Linköpings universitet/Tekniska fakulteten

    Författare :Alex Knutsson; Jakob Unnebäck; [2023]
    Nyckelord :importance sampling; deep learning; gradient norm; AI; digital pathology; neural networks;

    Sammanfattning : Artificial neural networks are networks made up of thousands and sometimes millions or more nodes also referred to as neurons. Due to the sheer scale of a network, the task of training the network can become very compute-intensive. LÄS MER