Sökning: "Total oxidizable precursor assay TOP assay"
Visar resultat 1 - 5 av 6 uppsatser innehållade orden Total oxidizable precursor assay TOP assay.
1. Do selected CF3-containing pharmaceuticals oxidize to trifluoroacetic acid (TFA)? – Analysis of ultra-short perfluoroalkyl acids (PFAAs) and their analytical challenges following oxidation
Kandidat-uppsats, Örebro universitet/Institutionen för naturvetenskap och teknikSammanfattning : Total oxidizable precursor assay (TOPA) has been used to understand the contribution of unknown precursors to the extractable organofluorine (EOF) compounds. The investigation of compounds containing a CF3 moiety especially connected to an aromatic ring is important because any compounds with such a moiety (pharmaceuticals) may oxidize to form trifluoroacetic acid (TFA). LÄS MER
2. Could fluorinated pharmaceuticals have an impact on the EOF amount in human blood?
Kandidat-uppsats, Örebro universitet/Institutionen för naturvetenskap och teknikSammanfattning : Recent studies have discovered an increasing amount of unknown organofluorine in human blood. This increase insinuate that humans might be exposed to potentially new and unidentified organofluorine compounds. LÄS MER
3. Total oxidizable precursor assay: Applications and limitations. A study on the occurrence of perfluoroalkyl and polyfluoroalkyl substances (PFASs) in Chinese Wastewater Treatment Plants
Master-uppsats, Örebro universitet/Institutionen för naturvetenskap och teknikSammanfattning : Total oxidizable precursor (TOP) assay is an in-lab method which oxidatively converts precursor compounds of poly- and perfluoroalkyl substances (PFASs) into measurable perfluorinated alkyl acids (PFAAs). The method is a very strong tool to semi-quantify PFASs that would otherwise be missed in conventional targeted analysis using liquid chromatography - tandem mass spectrometry (LC-MS/MS). LÄS MER
4. The study of organofluorine analysis applied to totaloxidizable precursor (TOP) assay to understand perandpolyfluoroalkyl substances (PFASs)
Kandidat-uppsats, Örebro universitet/Institutionen för naturvetenskap och teknikSammanfattning : Per- and polyfluoroalkyl substances (PFASs) are synthetic chemicals which are used in a wide range of applications such as aqueous film forming foam (AFFF) for firefighting, paint, coating and cosmetics. For almost a decade, PFASs have received worldwide attention because of the ubiquitous detection of PFAS in the environment and their bioaccumulative, persistent and give toxic effects on animals and humans. LÄS MER
5. A study to understand the information gap between total organofluorine analysis and total oxidizable precursor assay on polyfluoroalkyl/perfluoroalkyl substances (PFASs)
Kandidat-uppsats, Örebro universitet/Institutionen för naturvetenskap och teknikSammanfattning : Total oxidizable precursor (TOP) assay is an oxidation method to convert precursor compound of polyfluoroalkyl/perfluoroalkyl substances (PFASs) into measurable perfluorinated carboxylic acids (PFCAs). A previous mass balance study has shown that a loss of fluorine was observed after employing the method to convert the precursors in firefighting foams. LÄS MER
