Sökning: "Transdifferentiation"

Hittade 2 uppsatser innehållade ordet Transdifferentiation.

  1. 1. Modelling conversion of adult skin cells to neurons

    Master-uppsats, Lunds universitet/Institutionen för astronomi och teoretisk fysik; Lunds universitet/Beräkningsbiologi och biologisk fysik

    Författare :Viktor Drugge; [2018]
    Nyckelord :Human adult fibroblast; Neuron; Neural conversion; Transdifferentiation; Direct reprogramming; Direct lineage conversion; Simulation; Regulatory gene network; Gene network topology; Gene circuit; Gene dynamics; Physics and Astronomy;

    Sammanfattning : Scientists are now able to directly convert one somatic cell type into another using a procedure known as direct lineage reprogramming or transdifferentiation. In this procedure, transcription factors which are important for initiating a rewriting of the gene expressions are introduced in the cell. LÄS MER

  2. 2. Exploring the Potential of CRISPRa and CRISPRi to Systematically Dissect Fate Options in Hematopoiesis

    Master-uppsats, Lunds universitet/Tillämpad biokemi

    Författare :Alexandra Bäckström; [2017]
    Nyckelord :Applied biochemistry; tillämpad biokemi; Chemistry; Technology and Engineering;

    Sammanfattning : Advances in our understanding of hematopoietic stem cells (HSCs) have enabled the establishment of differentiation pathways throughout the hematopoietic hierarchy. To further explore the molecular cues governing cell fate options, there is a need to manipulate gene function in a controllable manner. LÄS MER