Sökning: "UPLC Q-TOF MS"

Hittade 4 uppsatser innehållade orden UPLC Q-TOF MS.

  1. 1. Using metabolic profiles to screen for novel compounds in deep-sea sponges

    Uppsats för yrkesexamina på avancerad nivå, Uppsala universitet/Institutionen för farmaceutisk biovetenskap

    Författare :Samira Hilowle; [2022]
    Nyckelord :Metabolomics; Deep-sea sponges;

    Sammanfattning : The chemical diversity of the phylum Porifera have provided marine natural products (MNPs) such as alkaloids, terpenoids and peptides with ranging biological activity. Every two days a novel compound deriving from sponges are discovered. LÄS MER

  3. 2. Conditioning of chromatographic systems prior to metabolomic studies : Investigation of the conditioning effect and the possibility to alter it

    Uppsats för yrkesexamina på avancerad nivå, Uppsala universitet/Avdelningen för analytisk farmaceutisk kemi

    Författare :Jasmin Telo; [2017]
    Nyckelord :Analytical chemistry; metabolomics; metabonomics; conditioning; conditioning effect; UPLC; Q-TOF; HILIC; Protein precipitation; Liquid-liquid extraction;

    Sammanfattning : The conditioning effect in metabolomic studies is the phenomenon of initial variation of analytical results in the first 5-10 injections of a biological sample in chromatographic systems. The deviation manifests itself as a drift in retention time, peak area and in multivariate analysis. LÄS MER

  4. 3. Development and evaluation of sample preparation procedure for human plasma samples in LC/MS-based metabolomics

    Uppsats för yrkesexamina på avancerad nivå, Uppsala universitet/Avdelningen för analytisk farmaceutisk kemi

    Författare :Niklas Kölfeldt; [2015]
    Nyckelord :metabolomics; LC; MS; UPLC; Q-TOF; SPE; Ultrafiltration; precipitation; C18; HILIC; QC; features;

    Sammanfattning : The aim of this master thesis project was to develop methods for sample preparation and analysis by LC-MS suitable for global metabolomics of human plasma samples. In this thesis six different methods was tested, based on precipitation, solid phase extraction (SPE), and ultrafiltration. LÄS MER

  5. 4. The investigation of the biotransformation products formed by Cunninghamella elegans for different classes of drugs by the use of UPLC Q-TOF MS

    Uppsats för yrkesexamina på avancerad nivå, Uppsala universitet/Avdelningen för analytisk farmaceutisk kemi

    Författare :Hanna Thorén; [2015]
    Nyckelord :UPLC Q-TOF MS; Glucosides; Glucuronides; TEMPO reaction; Cunninghamella elegans;

    Sammanfattning : The fungus Cunninghamella elegans has in many studies shown to have abiotransformation similar to the metabolism of mammals. If the biotransformation isgeneral, it enables the production of metabolites by the fungus and the use asreference material. The purpose of the project were to examine whether themetabolic process of C. LÄS MER