Sökning: "Ubiquitin ligases"

Hittade 2 uppsatser innehållade orden Ubiquitin ligases.

1. 1. Chemical design, synthesis and biological evaluation of novel proteolysis targeting chimeras (PROTACs) for the degradation of NUDT5

   Uppsats för yrkesexamina på avancerad nivå, Uppsala universitet/Preparativ läkemedelskemi

   Författare :Gabriel Tidestav; [2020]
   Nyckelord :protac; proteolysis targeting chimera; targetted protein degradation; nudt5; breast cancer; e3 ligase; ligands; vhl; crbn; theophylline;

   Sammanfattning : Proteolysis targeting chimeras (PROTACs) represent a new modality in drug design. They are bifunctional molecules; with one end, they bind to a protein of interest, and with the other end, they bind to endogenous E3 ligases. LÄS MER

3. 2. Identification of Novel Regulators of Mitochondrial Protein Quality Control

   Master-uppsats, Lunds universitet/Tillämpad biokemi

   Författare :My Bratbakken Lundvall; [2015]
   Nyckelord :Mitochondrial Quality Control; Oxidative Stress; Ubiquitin ligases; Ubiquitin; Yeast; Parkinson s Disease; Mitochondria; Paraquat; Oxidative Damage; Superoxides; tillämpad biokemi; applied biochemistry; Technology and Engineering; Chemistry; Biology and Life Sciences;

   Sammanfattning : Chronic pesticide exposure has been linked to several human diseases including cancer, Parkinson’s disease, Alzheimer’s disease, multiple sclerosis, cardiovascular disease, and kidney disease. Due to the potential risks to human health, the usage of pesticides has been a controversial topic. LÄS MER