Sökning: "Ubiquitin proteasome system UPS"

Hittade 1 uppsats innehållade orden Ubiquitin proteasome system UPS.

  1. 1. Inhibitory effect on the proteasome regulatory subunit, RPN11/POH1, with the use of Capzimin-PROTAC to trigger apoptosis in cancer cells

    Kandidat-uppsats, Linköpings universitet/Kemi

    Författare :Andreas Holmqvist; [2020]
    Nyckelord :Proteolysis targeting chimera PROTAC ; Cancer therapeutics; Ubiquitin proteasome system UPS ; Cancer; Chemotherapy; Proteasome inhibitor; Capzimin;

    Sammanfattning : Most patients diagnosed with cancer will receive systematic chemotherapy at some point during their illness, which almost always cause severe side effects for the patients such as, anemia, nausea and vomiting. The problems with today’s chemotherapy is not only that it cause severe side effects, but also that the cancer may develop resistance to the therapy, which is why the development of a new type of therapeutic agent is in dire need. LÄS MER