Sökning: "ZBED6"

Hittade 5 uppsatser innehållade ordet ZBED6.

  1. 1. Characterization of DNA binding of the two zinc finger domains of transcription factor zBED6

    Master-uppsats, Uppsala universitet/Institutionen för biologisk grundutbildning

    Författare :Alexander Taubert; [2019]
    Nyckelord :transcription factor; zinc finger; zBED6;

    Sammanfattning : The zinc finger protein, zBED6, is a transcriptional regulator of IGF2 along with hundreds of other genes relating to development and growth. Studies on the growth of commercially bred pigs discovered a single nucleotide substitution in the third intron of IGF2 which disrupts the binding of zBED6 and is responsible for the three-fold upregulation of IGF2 in skeletal muscle. LÄS MER

  3. 2. Identification of protein-interaction partners of ZBED6

    Master-uppsats, SLU/Dept. of Animal Breeding and Genetics

    Författare :Mi Zhou; [2012]
    Nyckelord :ZBED6; transcription factor; BAC TransgeneOmics; tandem affinity purification; protein interaction;

    Sammanfattning : ZBED6 was recently discovered as a novel transcriptional repressor of IGF2 because a mutation disrupting one of its binding sites in porcine IGF2 intron 3 leads to greater postnatal IGF2 expression in skeletal muscle and makes pig grow more muscle. ZBED6 is unique to placental mammals and derived from domesticated DNA transposon. LÄS MER

  4. 3. ZBED6 
expression 
pattern
 during 
embryogenesis
 and 
in
 the 
central 
nervous
 system

    Kandidat-uppsats,

    Författare :Axel Ericsson
; [2011]
    Nyckelord :;

    Sammanfattning : .... LÄS MER

  5. 4. Bioinformatics analysis of ZBED6, a novel transcription factor in mammals

    Master-uppsats, SLU/Dept. of Animal Breeding and Genetics

    Författare :Shumaila Sayyab; [2010]
    Nyckelord :Chromatin Immuno precipitation ChIP sequencing; non-coding RNA; transcription factor; overrepresentation; enhancer elements; co regulation; repressor;

    Sammanfattning : The identification of a regulatory mutation in the intron 3 of Insulin like growth factor 2, was a major finding. This single nucleotide mutation in the non coding region abrogates the interaction of nuclear factor ZBED6, resulting in the 3-4% increase in the muscle mass of domesticated pigs. LÄS MER

  7. 5. Bioinformatics analysis of ZBED6 : interactome of Novel Transcription Factor ZBED6 in C2C12 Myoblasts

    Master-uppsats, SLU/Dept. of Animal Breeding and Genetics

    Författare :Awaisa Ghazal; [2010]
    Nyckelord :Ingenuity Pathway Analysis IPA ; C2C12 myoblasts; Chromatin Immunoprecipitation ChIP ; Microarray; Myogenesis; ZBED6;

    Sammanfattning : ZBED6 is a novel mammalian transcription factor that was recently identified and shown to act as a repressor of IGF2 transcription in skeletal muscle. Chromatin Immunoprecipitation (ChIP) sequence data in murine C2C12 myoblasts indicated that ZBED6 holds 2499 targeting sites. LÄS MER