Sökning: "and mRNA applications."

Hittade 5 uppsatser innehållade orden and mRNA applications..

  1. 1. mRNA-based pharmaceuticals : A literature study based on current knowledge of mRNA

    Kandidat-uppsats, Uppsala universitet/Institutionen för kemi - Ångström

    Författare :Alicia Andersson; Isabella Åkerfeldt; Amanda Borgenstam; Ellinor Olsson; Adam Nyström; [2022]
    Nyckelord :mRNA-pharmaceuticals; mRNA therapies; mRNA vaccines; mRNA components; mRNA design; and mRNA applications.;

    Sammanfattning : This literature study provides a comprehensive overview of the current knowledge of mRNA-based pharmaceuticals, technologies and applications.  mRNA-based pharmaceuticals have newly been bought into focus as a potential brand-new drug class and many believe that it has the potential to transform areas of medicine. LÄS MER

  3. 2. Generation of induced pluripotent stem cells (iPSCs) lines deficient for genes associated with neurodevelopmental diseases using CRISPR/Cas9 technology

    Master-uppsats, Uppsala universitet/Institutionen för biologisk grundutbildning

    Författare :Claudia De Guidi; [2021]
    Nyckelord :;

    Sammanfattning : Induced pluripotent stem cells (iPSCs) can self-renew and differentiate into many other cell types. IPSCs are derived from somatic cells, and upon reprogramming, they share an expression profile similar to embryonic stem cells (ESCs). LÄS MER

  4. 3. Personalized Medicine

    Kandidat-uppsats, Uppsala universitet/Institutionen för biologisk grundutbildning

    Författare :Sarah Götze; Daniella Ekström; Tore Larsson Forssén; Eric Sjöö; Emma Svanberg Frisinger; Linnea Wikström; [2021]
    Nyckelord :Personalized medicine;

    Sammanfattning : The aim of this project was to present several therapies and possible applications of these in the field of personalized medicine along with the production techniques and workflows surrounding them. There are two main categories; cell therapies and non-cell therapies. LÄS MER

  5. 4. Modeling the intronic regulation of Alternative Splicing using Deep Convolutional Neural Nets

    Master-uppsats, KTH/Skolan för datavetenskap och kommunikation (CSC)

    Författare :Johannes Linder; [2015]
    Nyckelord :Machine Learning; Deep Learning; CNN; CNNs; Convolutional Neural Networks; Convolutional Neural Nets; Neural Networks; Neural Nets; Synthetic Biology; Alternative Splicing; AS; Splicing; DNA Regulation; Synthetic DNA; Massively Parallel Library; Maskinlärning; CNN; CNNs; Convolutional Neural Networks; Convolutional Neural Nets; Faltning; Neurala Nätverk; Neurala Nät; Syntetisk Biologi; Alternativ Splicing; Splicing; AS; DNA; Massivt Parallellt Bibliotek; Syntetiskt DNA;

    Sammanfattning : This paper investigates the use of deep Convolutional Neural Networks for modeling the intronic regulation of Alternative Splicing on the basis of DNA sequence. By training the CNN on massively parallel synthetic DNA libraries of Alternative 5'-splicing and Alternatively Skipped exon events, the model is capable of predicting the relative abundance of alternatively spliced mRNA isoforms on held-out library data to a very high accuracy (R2 = 0. LÄS MER

  7. 5. Development of Peptide Nucleic Acid Based Artificial Ribonucleases, PNAzymes

    Master-uppsats, Akademin för hållbar samhälls- och teknikutveckling

    Författare :Sara Andersson; [2010]
    Nyckelord :;

    Sammanfattning : Since mRNA plays such a vital role in the transfer of genetic code from DNA to proteins, approaches involving interference with mRNA are of great interest for use in therapeutics. Amongst these, peptide nucleic acid based nuclease systems (PNAzymes) are being developed for in vivo gene silencing in future. LÄS MER