Sökning: "bioinformatics"

Visar resultat 21 - 25 av 187 uppsatser innehållade ordet bioinformatics.

  1. 21. Dual RNA-seq analysis of gene co-expression and immune response mechanisms in chickens infected by Eimeria tenella

    Uppsats för yrkesexamina på avancerad nivå, Uppsala universitet/Institutionen för biologisk grundutbildning

    Författare :Alma Hansen; [2023]
    Nyckelord :RNA-seq; Eimeria; bioinformatics; gene co-expression;

    Sammanfattning : Coccidiosis caused by Eimeria parasites is a worldwide problem, affecting chickens and leading to great losses in the poultry industry. Current vaccines are costly and non-optimal, and the parasite has developed resistance to the anticoccidials in use. LÄS MER

  3. 22. Identifying cell type-specific proliferation signatures in spatial transcriptomics data and inferring interactions driving tumour growth

    Uppsats för yrkesexamina på avancerad nivå, Uppsala universitet/Neuroonkologi och neurodegeneration

    Författare :Felix Wærn; [2023]
    Nyckelord :spatial transcriptomics; breast cancer; dimensionality reduction; bioinformatics; deconvolution;

    Sammanfattning : Cancer is a dangerous disease caused by mutations in the host's genome that makes the cells proliferateuncontrollably and disrupts bodily functions. The immune system tries to prevent this, but tumours have methods ofdisrupting the immune system's ability to combat the cancer. LÄS MER

  4. 23. Developing a reproducible bioinformatics workflow for canine inherited retinal disease

    Master-uppsats, Uppsala universitet/Institutionen för biologisk grundutbildning

    Författare :Melina Toni Marie Martin; [2023]
    Nyckelord :CanFam4; Nextflow; Inherited Retinal Degeneration; dog; whole-genome sequencing; bioinformatics;

    Sammanfattning : Inherited Retinal Degenerations (IRDs) are a heterogenous group of diseases which lead to vision impairment and can be found both in humans and in dogs. About 1 in 1,380 humans is estimated to suffer from an autosomal recessive IRD, which would be 5.5 million people worldwide, and many more are estimated to be unaffected carriers. LÄS MER

  5. 24. Single-cell RNA-seq mapping of chicken leukocytes : An investigation into single-cell transcriptomics as an alternative to traditional immunological methods within non-traditional model organisms

    Uppsats för yrkesexamina på avancerad nivå, Uppsala universitet/Mikrobiologi och immunologi

    Författare :Matilda Maxwell; [2023]
    Nyckelord :Bioinformatics; scRNA-seq; avian; immunology; Seurat; leukocytes; chicken; gallus gallus; 10x genomics; PCA;

    Sammanfattning : The immune system is a complex infrastructure where many cells interact with each other and perform duties depending on their type and function. When using traditional immunological methods in studying non-traditional model organisms, such as birds, challenges arise. LÄS MER

  7. 25. Molecular mapping of the HGSOC tumour microenvironment

    Master-uppsats, Uppsala universitet/Institutionen för medicinsk biokemi och mikrobiologi

    Författare :Philippine Louail; [2023]
    Nyckelord :Immunology; Ovarian cancer; Multiplex Immunofluorescence; scRNA sequencing; Bioinformatics; Image analysis;

    Sammanfattning : High-grade serous ovarian cancer (HGSOC) is the most aggressive subtype of ovarian cancer, and its heterogeneity poses a challenge for the discovery of reliable diagnostic biomarkers, therapeutic targets, and predicting treatment response, particularly to immunotherapy. The current standard diagnostic and treatment options are inadequate, resulting in late diagnosis and poor prognosis. LÄS MER