Sökning: "bioinformatik"

Visar resultat 1 - 5 av 55 uppsatser innehållade ordet bioinformatik.

1. 1. Prediction of multiple conformational states of membrane proteins

   Master-uppsats, Linköpings universitet/Bioinformatik

   Författare :Tobias Thorén; [2024]
   Nyckelord :Bioinformatics; Protein prediction; AlphaFold;

   Sammanfattning : Predicting protein structures has long been an area of active research in the field ofbioinformatics. Great strides have recently been made in this area by googles DeepMindteam. They developed an AI called AlphaFold which is able to make the most accuratepredictions of protein structures as of date. LÄS MER

3. 2. Analyzing the performance of active learning strategies on machine learning problems

   Uppsats för yrkesexamina på avancerad nivå, Uppsala universitet/Avdelningen för systemteknik

   Författare :Vendela Werner; [2023]
   Nyckelord :computer science; bioinformatics; machine learning; active learning; artificial intelligence; supervised learning; Astrazeneca; maskininlärning; artificiell intelligens; datorvetenskap; active learning; bioinformatik; supervised learning;

   Sammanfattning : Digitalisation within industries is rapidly advancing and data possibilities are growing daily. Machine learning models need a large amount of data that are well-annotated for good performance. To get well-annotated data, an expert is needed, which is expensive, and the annotation itself could be very time-consuming. LÄS MER

4. 3. Design and Evaluation of Peptide Binders : In silico evaluation and comparison of generative AI for de novo peptide binder design

   Uppsats för yrkesexamina på avancerad nivå, Uppsala universitet/Beräkningsbiologi och bioinformatik

   Författare :Linde Brokmar; [2023]
   Nyckelord :Protein design; de novo design; protein engineering; generative ai; machine learning; peptide binders; AF2; EvoBind; RFdiffusion; ProteinMPNN;

   Sammanfattning : Peptide binders are short proteins that bind to larger proteins. Due to peptide binders having high specificity and being cheap to synthesize, they are a prime candidate for drug design. Creating new proteins in silico can be divided into three steps: protein backbone generation, sequence design, and computational filtering. LÄS MER

5. 4. SubKluster: Novel method to bin scaffolds from cereal genomes into subgenomes using substring frequency analysis

   Master-uppsats, Lunds universitet/Examensarbeten i bioinformatik

   Författare :Victor Kalbskopf; [2023]
   Nyckelord :Biology and Life Sciences;

   Sammanfattning : The genome of the Belinda variety of the hexaploid oat (Avena sativa) has recently been sequenced and assembled. This project aims to improve the assembly by clustering the thousands of scaffolds into their three ancestral subgenomes using Principle Component Analysis (PCA) of kmer and repeat-element frequencies. LÄS MER

7. 5. Pseudomonas aeruginosa gene expression analysis using pangenome and PAO1 reference genomes

   Master-uppsats, Lunds universitet/Examensarbeten i bioinformatik

   Författare :Yi Su; [2023]
   Nyckelord :Biology and Life Sciences;

   Sammanfattning : Development in sequencing technologies has made the analyses of genetic material much more accessible. Processing sequenced data for an accurate analysis comes with its challenges, especially with the studies in microbial in clinical in vivo samples where difficulties in the collection of these samples for sequencing could lower the quality and contamination from the human host which might affect the accuracy of downstream analysis. LÄS MER