Sökning: "carbapenemases"

Hittade 5 uppsatser innehållade ordet carbapenemases.

1. 1. The Binding Mechanism of Carbapenems in the Class A beta-lactamase IMI-1 : A Molecular Dynamics Study of Ligand Stability

   Uppsats för yrkesexamina på avancerad nivå, Uppsala universitet/Biokemi

   Författare :Isabell Lindahl; [2022]
   Nyckelord :antibiotic resistance; IMI-1; betalactamase; Carbapenemase; free energy; LIE; linear interaction energy; β-lactamase; meropenem; biapenem; imipenem; active site;

   Sammanfattning : Antibiotic resistance is a global and accelerating matter. Over time, the bacteria have evolved several defense mechanisms against the antibiotics. One of the defense mechanisms is that the bacteria can produce enzymes with the ability to hydrolyze the characteristic b-lactam ring of the antibiotics. These enzymes are called b-lactamases. LÄS MER

3. 2. Antibiotic combination therapies against carbapenamse producing Klebsiella pneumoniae

   Master-uppsats, Uppsala universitet/Institutionen för biologisk grundutbildning

   Författare :Thomas Söderhäll; [2021]
   Nyckelord :Klebsiella pneumoniae; carbapenem resistance; carbapenemase; combination therapy; meropenem; colistin; avibactam; constucts; porins;

   Sammanfattning : The treatment options for multidrug resistant bacteria are dwindling and it is an important issue of research in medicine to solve. One of the more problematic bacterial species is Klebsiella pneumoniae, it can cause infections with high morbidity that are difficult to treat. LÄS MER

4. 3. Matrix Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometry som verktyg för att detektera nedbrytning av Ceftolozan/Tazobaktam orsakad av karbapenemaser

   Kandidat-uppsats, Örebro universitet/Institutionen för hälsovetenskaper

   Författare :Bessem Saad; [2020]
   Nyckelord :MALDI-TOF MS; Ceftolozane Tazobactam; carbapenemases; hydrolysis; decarboxylation; MALDI-TOF MS; Ceftolozan Tazobaktam; karbapenemaser; hydrolys; dekarboxylering;

   Sammanfattning : Under senare år har en särskilt hög resistensutveckling observerats hos gramnegativa bakterier inom familjen Enterobacteriaceae. Den främsta resistensmekanismen utgör produktion av så kallade "extended-spectrum β-lactamases" (ESBL) och särskilt oroväckande är karbapenemaser (ESBLCARBA) som har förmåga att bryta ner ett flertal olika grupper av β-laktamantibiotika. LÄS MER

5. 4. Screening for double carbapenem therapies effective against multidrug resistant Enterobacteriaceae

   Master-uppsats, Uppsala universitet/Institutionen för medicinsk biokemi och mikrobiologi

   Författare :Karin Vickberg; [2019]
   Nyckelord :Combination therapy; Carbapenem resistance; Carbapenemase; Carbapenem-resistant Enterobacteriaceae CRE ; Carbapenemase-producing Enterobacteriaceae; Klebsiella pneumoniae carbapenemase KPC ; New Delhi metallo-b-lactamase NDM ; Oxacillinase OXA ; Ertapenem ETP ; Doripenem DOR ; Meropenem MEM ; Broth microdilution BMD ; Time-lapse microscopy oCelloScope ; Time-kill experiments; Synergy;

   Sammanfattning : Multidrug resistant bacteria account for one of the biggest threats to human health in the future. One treatment option to be evaluated is antibiotic combination therapy. For this purpose, last- line carbapenems have been suggested, even when bacteria are resistant, e.g. LÄS MER

7. 5. Development of a bacterial infection model in zebrafish embryos with special focus on colistin-resistant Klebsiella pneumoniae

   Master-uppsats, Uppsala universitet/Institutionen för medicinsk biokemi och mikrobiologi

   Författare :Anna Tamara Leber; [2019]
   Nyckelord :Danio rerio; embryo model; microinjection; innate immunity; inflammation; Klebsiella pneumoniae; colistin-resistance; antimicrobial peptides; cross-resistance;

   Sammanfattning : Zebrafish (Danio rerio) is a promising model organism for immunological studies. A time window between the development of the innate and adaptive immune system makes it possible to investigate the mechanisms originating exclusively from the innate immune system. LÄS MER