Sökning: "carbapenems"

Visar resultat 1 - 5 av 8 uppsatser innehållade ordet carbapenems.

  1. 1. The Binding Mechanism of Carbapenems in the Class A beta-lactamase IMI-1 : A Molecular Dynamics Study of Ligand Stability

    Uppsats för yrkesexamina på avancerad nivå, Uppsala universitet/Biokemi

    Författare :Isabell Lindahl; [2022]
    Nyckelord :antibiotic resistance; IMI-1; betalactamase; Carbapenemase; free energy; LIE; linear interaction energy; β-lactamase; meropenem; biapenem; imipenem; active site;

    Sammanfattning : Antibiotic resistance is a global and accelerating matter. Over time, the bacteria have evolved several defense mechanisms against the antibiotics. One of the defense mechanisms is that the bacteria can produce enzymes with the ability to hydrolyze the characteristic b-lactam ring of the antibiotics. These enzymes are called b-lactamases. LÄS MER

  2. 2. Screening for carbapenemase-associated biomarkers in Klebsiella oxytoca using matrixassisted laser desorption/ionization time of flight mass spectrom

    Kandidat-uppsats, Örebro universitet/Institutionen för naturvetenskap och teknik

    Författare :Hannah Uppström; [2022]
    Nyckelord :MALDI-TOF MS; carbapenems; Verona integron-encoded metallo-β-lactamase; carbapenem resistance; AST biomarkers;

    Sammanfattning : Antibiotic resistant bacteria are threatening human health, and the resistance is progressingfaster than the development of new antimicrobial compounds. Antibiotic resistant infections cost enormous sums of money and resources, but most importantly human lives. LÄS MER

  3. 3. Antibiotic combination therapies against carbapenamse producing Klebsiella pneumoniae

    Master-uppsats, Uppsala universitet/Institutionen för biologisk grundutbildning

    Författare :Thomas Söderhäll; [2021]
    Nyckelord :Klebsiella pneumoniae; carbapenem resistance; carbapenemase; combination therapy; meropenem; colistin; avibactam; constucts; porins;

    Sammanfattning : The treatment options for multidrug resistant bacteria are dwindling and it is an important issue of research in medicine to solve. One of the more problematic bacterial species is Klebsiella pneumoniae, it can cause infections with high morbidity that are difficult to treat. LÄS MER

  4. 4. An Investigation of Cefadroxil and Meropenem’s Supply Chain and Estimationof the Health Economic Consequences in Sweden due to Shortage

    Kandidat-uppsats, Uppsala universitet/Institutionen för kemi - Ångström

    Författare :Christine Attemalm; Jonathan Efverström; Dania Elkhalifa; Viktor Hansen; Yasmine Sundelin Tjärnström; [2020]
    Nyckelord :cefadroxil; meropenem; supply chain; backorders; Swedish healthcare;

    Sammanfattning : Sweden has been increasingly affected by drug shortage and the public healthcare system has identified a large amount of antibiotics risking shortage. Drug shortage of antibiotics is a worldwide problem with complex causes and consequences affecting many countries healthcare systems. LÄS MER

  5. 5. Screening for double carbapenem therapies effective against multidrug resistant Enterobacteriaceae

    Master-uppsats, Uppsala universitet/Institutionen för medicinsk biokemi och mikrobiologi

    Författare :Karin Vickberg; [2019]
    Nyckelord :Combination therapy; Carbapenem resistance; Carbapenemase; Carbapenem-resistant Enterobacteriaceae CRE ; Carbapenemase-producing Enterobacteriaceae; Klebsiella pneumoniae carbapenemase KPC ; New Delhi metallo-b-lactamase NDM ; Oxacillinase OXA ; Ertapenem ETP ; Doripenem DOR ; Meropenem MEM ; Broth microdilution BMD ; Time-lapse microscopy oCelloScope ; Time-kill experiments; Synergy;

    Sammanfattning : Multidrug resistant bacteria account for one of the biggest threats to human health in the future. One treatment option to be evaluated is antibiotic combination therapy. For this purpose, last- line carbapenems have been suggested, even when bacteria are resistant, e.g. LÄS MER