Sökning: "cell biology"

Visar resultat 6 - 10 av 181 uppsatser innehållade orden cell biology.

  1. 6. Chromatin accessibility analysis of spaceflight mouse brains using ArchR

    Master-uppsats, KTH/Genteknologi

    Författare :Raphaël Mauron; [2023]
    Nyckelord :Single nuclei ATAC-sequencing; Space Biology; DNA Chromatin accessibility; Neurodegenerative; ArchR; ATAC-sekvensering av enskilda kärnor; rymdbiologi; tillgänglighet av DNA kromatin ; neurodegenerativa sjukdomar; ArchR;

    Sammanfattning : Mänsklig utforskning av månen och Mars innebär stora utmaningar för människans fysiologi och hälsa på grund av de unika miljöfaktorer som följer av långvariga rymduppdrag. Rymdbiologiska experiment har blivit ett viktigt verktyg för att studera effekterna som mikrogravitation och rymdstrålning har på levande organismer, i syfte att förstå och minska dessa utmaningar. LÄS MER

  3. 7. Characterization of Mitilysin Pores by Cryo-electron Microscopy

    Master-uppsats, Uppsala universitet/Institutionen för biologisk grundutbildning

    Författare :Vladimir Novakovic; [2023]
    Nyckelord :Mitilysin; Mly; Structural Biology; Cryo-EM; pore; toxin; pore forming proteins; pore forming toxins; PFP; PFT;

    Sammanfattning : Pore forming toxins (PFTs) are a large group of proteins found mainly in bacteria with some exceptions found in animals. They bind and form pores in their target membranes and form pores, which leads to cell death. Among these are cholesterol-dependent cytolysins (CDC), which require the presence of cholesterol to bind target membranes. LÄS MER

  4. 8. Computational prediction of cell-cell interactions in the brain-tumour microenvironment

    Master-uppsats, Uppsala universitet/Institutionen för biologisk grundutbildning

    Författare :Paula Camargo Romera; [2023]
    Nyckelord :Cancer; Glioblastoma; Computational Biology; Bioinformatics; Microenvironment; Brain tumour; Interactions; Systems Biology;

    Sammanfattning : Glioblastoma is the fastest-growing, and the most common malignant brain tumour in adults. It is normally treated with surgery and radio- or chemotherapy, but the approximate life expectancy is of 15 months with a high probability of cancer recurring. Therefore, there is a need for decreasing its severity. LÄS MER

  5. 9. Determining Protein Conformational Ensembles by Combining Machine Learning and SAXS

    Master-uppsats, KTH/Tillämpad fysik

    Författare :Samuel Eriksson Lidbrink; [2023]
    Nyckelord :AlphaFold; AlphaFold2; SAXS; protein conformational ensembles; machine learning; protein conformations; reweighting; SAXS; AlphaFold; AlphaFold2; proteinkonformationsensembler; maskininlärning; proteinkonformationer; omviktning;

    Sammanfattning : In structural biology, immense effort has been put into discovering functionally relevant atomic resolution protein structures. Still, most experimental, computational and machine learning-based methods alone struggle to capture all the functionally relevant states of many proteins without very involved and system-specific techniques. LÄS MER

  7. 10. Neanderthal genome sequencing : A genetic research study

    Kandidat-uppsats, Uppsala universitet/Institutionen för arkeologi och antik historia

    Författare :Susanna Uhr; [2023]
    Nyckelord :aDNA; genome sequencing; method progression; Neanderthals; modern humans; genetic divergence; interbreeding; aDNA; genom sekvensering; metodutveckling; Neandertalare; moderna människor; genetisk splittring; korsning;

    Sammanfattning : The aim of this study is to provide information regarding the development of aDNA research. The essay also strives to distinguish eventual impact on previous and contemporary conceptions concerning Neanderthal and modern human genetic divergence and possible interbreeding between the two species. LÄS MER