Sökning: "channel gating"

Hittade 4 uppsatser innehållade orden channel gating.

  1. 1. Modulation of a model ligand-gated ion channel by amphetamine derivatives

    Uppsats för yrkesexamina på avancerad nivå, Uppsala universitet/Strukturbiologi

    Författare :Emelia Karlsson; [2022]
    Nyckelord :pentameric ligand-gated ion channels; sTeLIC; electrophysiology; psychostimulants; amphetamine derivatives;

    Sammanfattning : Pentameric ligand-gated ion channels are critical mediators of electrochemical signal transduction in neurons and other excitable cells, causing them to be important targets of psychoactive drugs. Structural data for these complex proteins are limited, particularly among eukaryotic family members and for the functionally critical open state. LÄS MER

  3. 2. Extraction of gating mechanisms from Markov state models of a pentameric ligand-gated ion channel

    Master-uppsats, KTH/Proteinvetenskap

    Författare :Dimitrios Karalis; [2021]
    Nyckelord :GLIC; Markov state models MSMs ; KL divergence; Machine Learning ML ; pentameric ligand-gated ion channel pLGIC ; channel gating;

    Sammanfattning : GLIC är en pH-känslig pentamerisk ligandstyrd jonkanal (pLGIC) som finns i cellmembranet hos prokaryoten Gloeobacter violaceus. GLIC är en bakteriell homolog till flera receptorer som är viktiga i nervsystemet hos de flesta eukaryotiska organismer. LÄS MER

  4. 3. Investigating the protein-protein Interaction between Aquaporin 4 & Calmodulin

    Magister-uppsats, Lunds universitet/Kemiska institutionen

    Författare :Zahraa Majhool; [2020]
    Nyckelord :aquaporin4 protein-protein; interaction calmodulin ; biochemistry; molecular biology; biokemi; molekylärbiologi; Chemistry;

    Sammanfattning : Around 60 million people around the world are struggling with a traumatic brain or spinal cord injury. The swelling of the brain or spinal cord happen when the water content in the CNS increase due, infection, tumor growth or brain edema. LÄS MER

  5. 4. On the Modelling of Kainate Receptor Channels

    Master-uppsats, KTH/Matematik (Avd.)

    Författare :Tahar Etienne Nabil; [2014]
    Nyckelord :;

    Sammanfattning : Kainate receptor channels are a class of ion channels found on the membrane of nerve cells. These proteins play a key role in the brain, since their properties regulate the strength of the synapses. LÄS MER