Sökning: "chaperones"

Visar resultat 1 - 5 av 7 uppsatser innehållade ordet chaperones.

  1. 1. Effect of DNAJB6 on α-synuclein amyloid fibril aggregation and dis-aggregation

    Uppsats för yrkesexamina på avancerad nivå, Lunds universitet/Biofysikalisk kemi

    Författare :Josef Getachew; [2023]
    Nyckelord :α-synuclein; alpha-synuclein; chaperones; DNAJB6; the unhappy chaperone; parkinsons disease; biophysical chemistry; biochemistry; Biology and Life Sciences; Chemistry; Technology and Engineering;

    Sammanfattning : Amyloid proteins are a group of proteins with the ability to form large fibrillar aggregates, identifiable by their cross-β core structure. These aggregates are linked to several different neurodegenerative diseases such as Parkinson’s disease and Alzheimer’s disease and due to the growing rate of people diagnosed, there is a need to combat these diseases. LÄS MER

  3. 2. In vivo characterization of Hsp104 variants in Saccharomyces cerevisiae

    Magister-uppsats, Högskolan i Skövde/Institutionen för biovetenskap

    Författare :Md. Mominur Rahman; [2021]
    Nyckelord :;

    Sammanfattning : Cell stress, caused by misfolded or aggregated proteins or exposure to certain environmental stressors, activates stress detectors and selected analysis processes within the cell, resulting intranscriptional regulation and synthesis of factors that influence appropriate folding or removal of misaligned proteins to recover proteostasis. Yeasts are given a sophisticated and interconnected system to restore from the disruption of proteostasis, which involves molecular chaperones and protein degradation pathways as significant participants. LÄS MER

  4. 3. The anti-amyloidogenic chaperone DNAJB6 and its interaction with other chaperones

    Kandidat-uppsats, Lunds universitet/Matematisk statistik; Lunds universitet/Kemiska institutionen

    Författare :Gemma Nilsson; [2020]
    Nyckelord :chaperones; DNAJB6; Hsc70; Hsp110; ATP-hydrolysis; Ab42; polyQ; biochemistry; biokemi; Chemistry;

    Sammanfattning : In order to maintain proteins’ functionality their native folding state must be preserved. Chaperones fold other proteins and DNAJ-chaperones may collaborate with Hsc70 chaperones to prevent aggregation of aggregation-prone peptides such as polyQ and Aβ42, which form fibrils in currently incurable diseases as Huntington’s and Alzheimer’s, respectively. LÄS MER

  5. 4. Investigating the function of GroES with hard-to-fold proteins in vivo

    L3-uppsats, Linköpings universitet/Kemi; Linköpings universitet/Tekniska fakulteten; Linköpings universitet/Institutionen för klinisk och experimentell medicin; Linköpings universitet/Medicinska fakulteten

    Författare :Oliver Hild Walett; Emmanuel Berlin; Johan Larsson; Sofie Arvidsson; Filip Fors; Marianne Gavelius; Filip Genander; Johanna Granqvist; Philip Lifwergren; Alexandra Sandéhn; Martin Viksten; Irma Wenhov; [2019]
    Nyckelord :;

    Sammanfattning : The use of molecular chaperones can increase the yield of correctly folded proteins. This is especially needed in the expression of proteins non-native to the host organism. This study set out to investigate the function of the chaperone GroES; a component in the GroE-system. The function of this chaperone has only been studied alone in vitro. LÄS MER

  7. 5. Unfolding the role of Ire1 and DNAJB1 in Parkinson’s disease

    Master-uppsats, Lunds universitet/Examensarbeten i molekylärbiologi

    Författare :Emma Källstig; [2017]
    Nyckelord :Biology and Life Sciences;

    Sammanfattning : Parkinson’s disease (PD) is a movement disorder of the brain which is hallmarked by the presence of large protein-rich cytoplasmic aggregates, called Lewy bodies (LBs), in the neurons. The protein α-synuclein (α-syn) is abundant in these aggregates, and can itself form aggregates. LÄS MER