Sökning: "cisplatin"

Visar resultat 1 - 5 av 15 uppsatser innehållade ordet cisplatin.

  1. 1. Evaluating LOAd703 in combination with chemotherapeutic agents in ovarian cancer

    Master-uppsats, Uppsala universitet/Institutionen för biologisk grundutbildning; Uppsala universitet/Institutionen för immunologi, genetik och patologi

    Författare :Jonas Härdin; [2022]
    Nyckelord :Clinical Immunology; Immunotherapy; LOAd; Ovarian Cancer; Oncology; Virus;

    Sammanfattning : Ovarian cancer is a disease with a high rate of mortality where the need for novel treatments will increase in the near future as older and populous generations reach the age where the cancer is usually diagnosed. Once treated, ovarian cancer tends to recur and display a newfound resistance against the platinum-based chemotherapeutic drugs that are used to treat the disease. LÄS MER

  3. 2. Combination of Antimetabolites with Chemotherapy as a Novel Treatment Option in High-risk Neuroblastoma

    Master-uppsats, KTH/Proteinvetenskap

    Författare :Maja Lundström; [2022]
    Nyckelord :cell cycle arrest; chemotherapy resistance; combination therapy; cytarabine; doxorubicin; gemcitabine;

    Sammanfattning : 20 svenska barn diagnostiseras årligen med barntumören neuroblastom (NB). Läkemedelsresistens och intratumoral heterogenitet försvårar behandlingen och 50-60% av hög-risk NB-patienter drabbas av återfall. Subpopulationer av resistenta celler har identifierats i hög-risk NB-cellinjer, vilket belyser behovet av nya behandlingsalternativ. LÄS MER

  4. 3. Investigation of endogenous p21 expression and its correlation to therapy resistance in high-risk neuroblastoma

    Master-uppsats, KTH/Proteinvetenskap

    Författare :Agnes Sorteberg; [2021]
    Nyckelord :p21; high-risk neuroblastoma; small molecular inhibitor; chemo-resistance; combination treatment;

    Sammanfattning : Neuroblastoma (NB) is a childhood cancer with a highly complex nature. High-risk NB patients undergo intensive treatment regimens that are often followed by long-term side effects. This, in addition to the emergence of resistant cancer cells, highlights a need for novel therapeutic targets and treatment strategies to improve outcome in NB. LÄS MER

  5. 4. Investigation of drug-induced cell cycle responses in high-risk neuroblastoma

    Master-uppsats, KTH/Skolan för kemi, bioteknologi och hälsa (CBH)

    Författare :Maryam Sahi; [2020]
    Nyckelord :Neuroblastoma; chemotherapy resistance; cell cycle arrest; cisplatin; doxorubicin; ATM; Chk1; Wee1; Neuroblastom; kemoterapiresistans; cellcykelarrest; cisplatin; doxorubicin; ATM; Chk1; Wee1;

    Sammanfattning : The childhood cancer neuroblastoma mostly affects children under the age of 2 and comprises 6% of all childhood cancers. Neuroblastoma has very diverse phenotypes caused by both inter- and intra-tumour heterogeneities. The phenotypes are classified as being either low- or high-risk. LÄS MER

  7. 5. PTA Ruthenium-aminochloroquinoline complexes: Antimalarials of the future

    Master-uppsats, Lunds universitet/Kemiska institutionen

    Författare :Maria Alejandra Silva Quintero; [2017]
    Nyckelord :Chemistry;

    Sammanfattning : Malaria is a disease that is transmitted by mosquitoes; it has been transmitedaffecting humanity for more than 10.000 years, it affects between 700 000 and 2.7million people per year and it can be deadly, therefore there is a large and increasinginterest in developing a cure against it. LÄS MER