Sökning: "clusterin"

Hittade 5 uppsatser innehållade ordet clusterin.

  1. 1. Development of specific host cell protein assays

    Uppsats för yrkesexamina på avancerad nivå, Uppsala universitet/Institutionen för biologisk grundutbildning

    Författare :Anna Ivert Nordén; [2023]
    Nyckelord :Gyrolab; Immunoassay; HCP;

    Sammanfattning : The manufacturing and the development of biotherapeutic drugs involves the expression of biotherapeutic proteins in a host cell expression system followed by a purification process. Bioanalytical methods to measure impurities such as host cell proteins (HCPs) are needed to obtain a robust process and a safe drug according to regulatory requirements. LÄS MER

  3. 2. The Largest Void and Cluster in Non-Standard Cosmology

    L3-uppsats, Uppsala universitet/Teoretisk astrofysik

    Författare :Sveva Castello; [2020]
    Nyckelord :Cosmology; f R gravity; galaxy clusters; cosmic voids; extreme value statistics;

    Sammanfattning : We employ observational data about the largest cosmic void and most massive galaxy cluster known to date, the 'Cold Spot' void and the 'El Gordo' cluster, in order to constrain the parameter |fR0| from the f(R) gravity formulation by Hu and Sawicki and the matter power spectrum normalization at present time, σ8. We obtain the marginalized posterior distribution for these two parameters through a Markov Chain Monte Carlo analysis, where the likelihood function is modeled through extreme value statistics. LÄS MER

  4. 3. Proteomics studies of Alzheimer’s Aβ-oligomers to identify interactions with other proteins in human serum and cerebrospinal fluid.

    Master-uppsats, SLU/Dept. of Molecular Biology (until 131231)

    Författare :Mahafuzur Rahman; [2012]
    Nyckelord :Alzheimer’s disease; Aβ oligomers; protein-protein interactions; serum; cerebrospinal fluid; proteomics; mass spectrometry;

    Sammanfattning : Alzheimer’s disease (AD) is the most common neurodegenerative disorder. The pathogenesis of AD is linked to the oligomerization and aggregation of the amyloid-β peptide (Aβ) into protein plaques in the brain. However, the role of these aggregates in the disease pathology remains largely unknown. LÄS MER

  5. 4. Prostasome ELISA - a potential marker for prostate cancer diagnosis

    Uppsats för yrkesexamina på grundnivå, Institutionen för medicinsk biokemi och mikrobiologi

    Författare :Elisabeth Thermaenius; [2012]
    Nyckelord :biomarker; immunoassay; exosome; PSA; vesicle;

    Sammanfattning : Abstract   The prostate gland, a male organ, situated right under the urine bladder, is involved in male reproduction. It can also be the place for more or less serious diseases such as inflammation, abnormal growth and cancer. Especially prostate cancer is very common in the Western world. LÄS MER

  7. 5. Co-localization of the astrocytic proteins Mts1 and clusterin in CNS injury

    Kandidat-uppsats, Institutionen för medicinsk biokemi och mikrobiologi

    Författare :Mirja Augustsson; [2005]
    Nyckelord :astrocytes; clusterin; GFAP; Mts1; parkin; spinal cord injury; astrocytic cultures; Ca-binding protein; chaperon; ABC;

    Sammanfattning : In the case of injury to the CNS, different proteins act to repair and protect cells in the brain and spinal cord. In the present study, we looked at dorsal root injury and hypoglossal nerve avulsion and transection. Here we studied for the first time the expression of Parkin in these types of injuries. LÄS MER