Sökning: "computational biology"

Visar resultat 6 - 10 av 44 uppsatser innehållade orden computational biology.

  1. 6. Predicting Biomarkers/ Candidate Genes involved in iALL, using Rough Sets based Interpretable Machine Learning Model.

    Master-uppsats, Uppsala universitet/Institutionen för biologisk grundutbildning

    Författare :Girish Pulinkala; [2023]
    Nyckelord :Machine Learning; Cancer; Oncology; Acute Lymphoblastic Leukemia; Rough sets; Pathway analysis; Feature selection; Bioinformatics; Computational Biology.;

    Sammanfattning : Acute lymphoblastic leukemia is a hematological malignancy that gains a proliferative advantage and originates in the bone marrow. One of the more common genetic alterations in ALL is KMT2A-rearrangement which constitutes 80% of the cases of ALL in infants. LÄS MER

  3. 7. Messing With The Gap: On The Modality Gap Phenomenon In Multimodal Contrastive Representation Learning

    Uppsats för yrkesexamina på avancerad nivå, Uppsala universitet/Industriell teknik

    Författare :Mohammad Al-Jaff; [2023]
    Nyckelord :Multimodal machine learning; Representation learning; Self-supervised learning; contrastive learning; computer vision; computational biology; bioinformatics;

    Sammanfattning : In machine learning, a sub-field of computer science, a two-tower architecture model is a specialised type of neural network model that encodes paired data from different modalities (like text and images, sound and video, or proteomics and gene expression profiles) into a shared latent representation space. However, when training these models using a specific contrastive loss function, known as the multimodalinfoNCE loss, seems to often lead to a unique geometric phenomenon known as the modality gap. LÄS MER

  4. 8. Computational modelling of photosynthetic excitons coupled to a microcavity

    Master-uppsats, Lunds universitet/Fysiska institutionen; Lunds universitet/Beräkningsbiologi och biologisk fysik - Genomgår omorganisation; Lunds universitet/Institutionen för astronomi och teoretisk fysik - Genomgår omorganisation

    Författare :Ilmari Turunen; [2022]
    Nyckelord :Cavity QED; LH2; Chlorophyll; Exciton; Polariton; Transition dipole moment; Absorbance; Physics and Astronomy; Chemistry; Biology and Life Sciences;

    Sammanfattning : Cavity quantum electrodynamics (QED) is a theory that is used for describing the interaction between matter and cavity modes. Not until relatively recently, cavity QED has been extended to the study of photosynthetic light-harvesting complexes (LHCs). LÄS MER

  5. 9. Aromatic Ring Flips and Local Volume Fluctuations in BPTI

    Master-uppsats, Lunds universitet/Biofysikalisk kemi

    Författare :Simon Enbom; [2022]
    Nyckelord :Biophysical Chemistry; Molecular Dynamics; Protein Dynamics; Activation Volume; Aromatic Ring Flips; BPTI; Biology and Life Sciences; Chemistry; Technology and Engineering;

    Sammanfattning : Aromatic ring flips are a classic example of a dynamic process in proteins. Discovered decades ago, methodological limitations hindered progress at the time. Ring flips have gained new interest and experimentalists can measure the flip rate and thermodynamic quantities associated with it. LÄS MER

  7. 10. Designing an optmized met X/Y enzymes for an efficient methionine production in E.coli

    Kandidat-uppsats, Högskolan i Skövde/Institutionen för biovetenskap

    Författare :Luísa Rodrigues; [2022]
    Nyckelord :;

    Sammanfattning : Methionine is a proteinogenic amino acid critical amino for the pharmaceutical, biotechnological and agricultural industries. The overall methionine biosynthetic pathway is as follows: 1. Acetylation of homoserine and its subsequent activation 2. Formation of homoserine through the replacement hydroxyl group by a thiol group, 3. LÄS MER