Sökning: "core genome"

Visar resultat 1 - 5 av 11 uppsatser innehållade orden core genome.

  1. 1. Pseudomonas aeruginosa gene expression analysis using pangenome and PAO1 reference genomes

    Master-uppsats, Lunds universitet/Examensarbeten i bioinformatik

    Författare :Yi Su; [2023]
    Nyckelord :Biology and Life Sciences;

    Sammanfattning : Development in sequencing technologies has made the analyses of genetic material much more accessible. Processing sequenced data for an accurate analysis comes with its challenges, especially with the studies in microbial in clinical in vivo samples where difficulties in the collection of these samples for sequencing could lower the quality and contamination from the human host which might affect the accuracy of downstream analysis. LÄS MER

  3. 2. Evaluation and implementation of quality control parameters for genome-wide DNA methylome sequencing

    Magister-uppsats, Högskolan i Skövde/Institutionen för biovetenskap

    Författare :Sara Ekberg; [2022]
    Nyckelord :;

    Sammanfattning : Epigenomics is the study of modifications to the genetic material without changes to the DNA sequence, one such modification is methylation of nucleotides. DNA methylation is associated with gene regulation and is studied in a variety of fields such as cancer and ageing. LÄS MER

  4. 3. Cancer Driver Gene Detection using Deep Convolutional Neural Networks on H3K4me3 Enrichment Profiles

    Master-uppsats, Lunds universitet/Institutionen för astronomi och teoretisk fysik - Genomgår omorganisation

    Författare :Marc Pielies Avellí; [2022]
    Nyckelord :Cancer Driver CD Gene; Histone Post-Translational Modifications PTMs ; Convolutional Neural Networks CNNs .; Physics and Astronomy;

    Sammanfattning : In spite of our current knowledge regarding the biology underlying cancer genesis, reliable methods for the discovery of cancer driver (CD) genes are still in great need. The rather recent incorporation of epigenetic markers to the cancer paradigm has nevertheless opened the door for the development of new computational approaches to the problem. LÄS MER

  5. 4. Study of the Genetic Dynamics in Pan-genomes for Six Bacterial Species

    Uppsats för yrkesexamina på avancerad nivå, Uppsala universitet/Institutionen för medicinsk biokemi och mikrobiologi

    Författare :Jennifer Johansson; [2021]
    Nyckelord :pan-genome; core genome; accessory genome; genetic dynamics;

    Sammanfattning : Foodborne diseases are a growing health problem today and can be caused by eating food contaminated with bacteria. To monitor known foodborne diseases, institutions keep track of bacteria in surveillance projects. Whole genome sequencing is becoming the new standard method for comparing isolates, which generates large amounts of data. LÄS MER

  7. 5. Developing a web based tool for identification of disease modules

    Magister-uppsats, Högskolan i Skövde/Institutionen för biovetenskap

    Författare :Emma Persson; [2018]
    Nyckelord :Modifier;

    Sammanfattning : Complex diseases such as cancer or obesity are thought to be caused by abnormalities in multiple  genes and cannot be derived to one specific location in the genome. It has been shown that  identification of disease associated genes can be made through looking at interaction patterns in a  protein‐protein interaction network, where the disease associated genes are represented in clusters,  or disease modules. LÄS MER