Sökning: "drug screening"

Visar resultat 1 - 5 av 39 uppsatser innehållade orden drug screening.

  1. 1. Fragment-screening by X-ray crystallography of human vaccinia related kinase 1

    Master-uppsats, Linköpings universitet/Institutionen för fysik, kemi och biologi

    Författare :Yousif Ali Rashid Majid; [2020]
    Nyckelord :Fragment based drug discovery; X-ray crystallography; screening; vaccinia related kinase 1; crystal optimization; fragment library design; differential scanning fluorimetry; Sprint Bioscience;

    Sammanfattning : Fragment-screening by X-ray crystallography (XFS) is an expensive and low throughput fragment drug discovery screening method, and it requires a lot of optimization for each protein target. The advantages with this screening method are that it is very sensitive, it directly gives the three-dimensional structure of the protein-fragment complexes, and false positives are rarely obtained. LÄS MER

  2. 2. 3D Bioprinting Meniscus for Future Tissue Replacement in Osteoarthritis Affected Knee Joints

    H-uppsats, Chalmers tekniska högskola / Institutionen för biologi och bioteknik

    Författare :Ida Pettersson; Amanda Olsson Widjaja; [2020]
    Nyckelord :Alginate; Articular Cartilage; Bioink; Induced Pluripotent Stem Cells; Meniscus; Nanofibrillated Cellulose; Osteoarthritis; Screening; 3D Bioprinting;

    Sammanfattning : Progressive cartilage defects in human knee joints are a worldwide health issue that exposes a great burden on society as well as on single individuals. Sudden traumas to the knees can induce tears in the structures of the joints such as the articular cartilage and the meniscus. LÄS MER

  3. 3. Conquering Chemical Space : Optimization of Docking Libraries through Interconnected Molecular Features

    Master-uppsats, Uppsala universitet/Institutionen för biologisk grundutbildning

    Författare :Leonard Sparring; [2020]
    Nyckelord :;

    Sammanfattning : Copied selected text to selection primary: The development of new pharmaceuticals is a long and ardous process that typically requires more than 10 years from target identification to approved drug. This process often relies on high throughput screening of molecular libraries. LÄS MER

  4. 4. Fragment screening using WAC towards new SMARCA4 inhibitors

    Master-uppsats, Lunds universitet/Centrum för analys och syntes

    Författare :Artur Sahakjan; [2020]
    Nyckelord :WAC; Fragments; SMARCA4; Library; Fragment Based Drug Discovery FBDD ; Peptide Synthesis; Affinity; Organic chemistry; Organisk kemi; Chemistry;

    Sammanfattning : The drug discovery and development process has changed dramatically during the last decades and the growth of more efficient techniques as high throughput screening combined with combinatorial synthesis using amino acids and carboxylic acids on solid support makes it possible to investigate the affinity of molecules towards a biological target. Fragment based drug discovery (FBDD) has been implemented into different techniques with purpose of discovering new drugs. LÄS MER

  5. 5. Skin Models for Screening of Topical Delivery

    Master-uppsats, KTH/Skolan för kemi, bioteknologi och hälsa (CBH)

    Författare :Johanna Carlsson; [2020]
    Nyckelord :Transdermal delivery; biological actives; topical formulations; penetration enhancers; skin models; permeation through skin; penetration into skin;

    Sammanfattning : The interest of drug delivery via the skin is progressively increasing due to its convenience and affordability. However, the skin has an effective barrier function which hinders drugs to penetrate. LÄS MER