Sökning: "drug screening"

Visar resultat 11 - 15 av 63 uppsatser innehållade orden drug screening.

  1. 11. The effects of urine adulteration with oxidants before drug analysis with LC-HRMS and CEDIA

    Kandidat-uppsats, Uppsala universitet/Institutionen för medicinsk cellbiologi

    Författare :Anna Nilsson; [2022]
    Nyckelord :Drugs of abuse; Manipulation; Mass spectrometry; Narcotics; Tampering;

    Sammanfattning : In drug analysis, different kinds of immunoassays are often used as an initial screening for urine samples. The positive screening results are then followed by a confirmatory test, which consists of mass spectrometry methods to detect the drugs. The confirmatory tests are considered to be more resistant to manipulation than the screening tests. LÄS MER

  3. 12. Development of Microfluidic 3D Cell Culture with a Nanocellulose-Based Scaffold for Spheroid Formation as a Potential Tool for Drug Screening

    Master-uppsats, KTH/Skolan för kemi, bioteknologi och hälsa (CBH)

    Författare :Sara Payande; [2022]
    Nyckelord :3D cell culture; Scaffold; Microfluidics; Layer-by-Layer; Cellulose Nanofibrils; Spheroids; HepG2; 3D cellodling; Matris; Mikrofluidik; Layer-by-Layer; Cellulosa Nanofibriller; Sfäroider; HepG2;

    Sammanfattning : Abstract  Lack of clinical relevance is assumed to be the main reason behind the high failure rate of medical drugs in the very initial phases of clinical trials. Clinical relevance is difficult to achieve with current tools as they lack the biological and physiological cues found in vivo. LÄS MER

  4. 13. Social Behavior in a Zebrafish Model of Schizophrenia

    Master-uppsats, KTH/Skolan för kemi, bioteknologi och hälsa (CBH)

    Författare :Dagmar Halldorsdottir; [2022]
    Nyckelord :Zebrafish; Schizophrenia; RNA binding motif protein 12 gene RBM12 ; Personal space; Average inter-fish distance; Anxiety-like behavior; Wall-hugging; Speed; Bottom-dwelling;

    Sammanfattning : Schizophrenia is a severe psychiatric disorder with unsatisfactory treatment options and poorly under- stood etiology. Genetic models are a suitable tool for studying this disorder with its high heritability. However, currently available animal models do not cover the broad range of schizophrenia symptoms and are not disorder-specific. LÄS MER

  5. 14. Structure-based design of new antiviral substances against the Venezuelan equine encephalitis virus

    Master-uppsats, Lunds universitet/Tillämpad biokemi; Lunds universitet/Beräkningskemi

    Författare :Elin Öberg; [2022]
    Nyckelord :x-ray crystallography; protein crystallization; Venezuelan equine encephalitis virus; structure-based drug design; applied biochemistry; Technology and Engineering;

    Sammanfattning : The Venezuelan equine encephalitis virus (VEEV) is a highly infectious alphavirus responsible for severe outbreaks and epidemics in the Americas. The nonstructural protein 2 (nsP2) cysteine protease plays a fundamental role in the VEEV replication process, and is therefore, an attractive drug target for structure-based drug design using x-ray crystallography. LÄS MER

  7. 15. SCREENING FOR IRF5 INHIBITORS

    Uppsats för yrkesexamina på avancerad nivå, Örebro universitet/Institutionen för naturvetenskap och teknik

    Författare :Elin Forsberg; [2021]
    Nyckelord :IRF5; inhibitor; drug;

    Sammanfattning : Interferon regulatory factor 5 (IRF5) is a protein with different functions including theactivation of genes that encode different cytokines. Overexpression of IRF5 has been observedto lead to different types of stress in the cells, including an overproduction of cytokines, whichis referred to as a cytokine storm. LÄS MER