Sökning: "drug screening"
Visar resultat 21 - 25 av 63 uppsatser innehållade orden drug screening.
21. Identification of novel loss of heterozygosity collateral lethality genes for potential applications in cancer
Master-uppsats, Uppsala universitet/Institutionen för biologisk grundutbildningSammanfattning : Over the course of this project, I demonstrate the utility of a 4-phase analysis pipeline in the context of cancer therapy and the associated search for antineoplastic drug candidates. I showcase a repeatable means for generating lists of potential targets which may be used in conjunction with methods like small molecule screening as part of a search for broadly effective antineoplastic agents. LÄS MER
22. 3D Bioprinting Meniscus for Future Tissue Replacement in Osteoarthritis Affected Knee Joints
H-uppsats,Sammanfattning : Progressive cartilage defects in human knee joints are a worldwide health issue that exposes a great burden on society as well as on single individuals. Sudden traumas to the knees can induce tears in the structures of the joints such as the articular cartilage and the meniscus. LÄS MER
23. Fragment-screening by X-ray crystallography of human vaccinia related kinase 1
Master-uppsats, Linköpings universitet/Institutionen för fysik, kemi och biologiSammanfattning : Fragment-screening by X-ray crystallography (XFS) is an expensive and low throughput fragment drug discovery screening method, and it requires a lot of optimization for each protein target. The advantages with this screening method are that it is very sensitive, it directly gives the three-dimensional structure of the protein-fragment complexes, and false positives are rarely obtained. LÄS MER
24. Conquering Chemical Space : Optimization of Docking Libraries through Interconnected Molecular Features
Master-uppsats, Uppsala universitet/Institutionen för biologisk grundutbildningSammanfattning : Copied selected text to selection primary: The development of new pharmaceuticals is a long and ardous process that typically requires more than 10 years from target identification to approved drug. This process often relies on high throughput screening of molecular libraries. LÄS MER
25. Fragment screening using WAC towards new SMARCA4 inhibitors
Master-uppsats, Lunds universitet/Centrum för analys och syntesSammanfattning : The drug discovery and development process has changed dramatically during the last decades and the growth of more efficient techniques as high throughput screening combined with combinatorial synthesis using amino acids and carboxylic acids on solid support makes it possible to investigate the affinity of molecules towards a biological target. Fragment based drug discovery (FBDD) has been implemented into different techniques with purpose of discovering new drugs. LÄS MER