Sökning: "dynamic light scattering"

Visar resultat 1 - 5 av 44 uppsatser innehållade orden dynamic light scattering.

  1. 1. Methods to study device induced aggregation of proteins

    Master-uppsats, Lunds universitet/Livsmedelsteknik och nutrition (master)

    Författare :Marie Therese von Wowern; [2023]
    Nyckelord :protein formulation; protein aggregation; insulin; silicone oil; syringe; shear stress; subvisible particle; size exclusion chromatography; flow imaging microscopy; pharmaceutical technology; Technology and Engineering;

    Sammanfattning : This work developed a method for the investigation of how medical devices, such as syringes and needles, affect the formation of subvisible particles in a protein drug without excipients. Protein-based pharmaceuticals are well known to be sensitive to different kinds of stress, and exposure to stress during the use of this device is unavoidable. LÄS MER

  3. 2. Investigation on Liquid-Liquid Phase Separation in Immunoglobulin G Solutions

    Kandidat-uppsats, Stockholms universitet/Fysikum

    Författare :Lovisa Jansson; [2023]
    Nyckelord :Protein; Liquid-Liquid Phase Separation; Microscopy; Light Scattering;

    Sammanfattning : Liquid-liquid phase separation (LLPS) is an important phenomenon in soft condensed matter that explains many properties of membraneless organelles in living cells. The research on this topic is, therefore, a field with a wide range of applications such as biopharmacy and biomaterials. LÄS MER

  4. 3. Optimising microfluidic preparation of lipid sponge phase nanoparticles for biomolecule encapsulation

    Master-uppsats, Lunds universitet/Kemiteknik (CI)

    Författare :Owais Khalil; [2023]
    Nyckelord :Sponge phase; lipid nanoparticles; microfluidics; SAXS; cryo-TEM; DLS; chemical engineering; Chemistry;

    Sammanfattning : Drug delivery with lipid nanoparticles, especially sponge phase lipid nanoparticles (LNP), has been well studied because of its ability for drug encapsulation and transferring the drug through the cell membrane. The sponge phase LNP formulation could be affected by the molecular structure of the lipid, the temperature, pH, dilution, the buffer, and the addition of a stabiliser. LÄS MER

  5. 4. Optimizing the Production of Aurora Kinase A and Validation of Constructs with different Sequential Lengths

    Master-uppsats, Linköpings universitet/Kemi

    Författare :Linnea Pierre; [2022]
    Nyckelord :Protein; Protein chemistry; Aurora Kinase A; Aurora A; Cancer; Structural Biology; Cancer research;

    Sammanfattning : Aurora Kinase A is a kinase involved in multiple signaling pathways and interactions during mitosis, making it an essential kinase that deregulated causes cancer diseases in affected patients. Structural research shows mainly static snapshots of possible conformations of the partly disordered protein. LÄS MER

  7. 5. Green Coacervates for Pharma and Food

    Master-uppsats, Lunds universitet/Livsmedelsteknik och nutrition (master)

    Författare :Izabella Imets; Andreas Vallin; [2022]
    Nyckelord :MSc; coacervate; biosurfactant; biopolymer; SAXS; DLS; elliposometry; pharmaceutical technology; Technology and Engineering;

    Sammanfattning : Anionic biosurfactant-cationic biopolymer systems were investigated to identify and characterize a coacervation window. The characterization of the systems was performed with dynamic light scattering, small angle x-ray scattering and in-situ ellipsometry. LÄS MER