Sökning: "efflux transport"

Visar resultat 1 - 5 av 7 uppsatser innehållade orden efflux transport.

1. 1. The Quantitative Expression of Transport Proteins SLC38A1-11 in Nerve Cell Development

   Uppsats för yrkesexamina på grundnivå, Uppsala universitet/Institutionen för farmaceutisk biovetenskap

   Författare :Maryam Dinar; [2023]
   Nyckelord :SLC38A1; SNAT1; SLC38A2; SNAT2; SLC38A3; SNAT3; SLC38A4; SNAT4; SLC38A5; SNAT5; SLC38A6; SNAT6; SLC38A7; SNAT7; SLC38A8; SNAT8; SLC38A9; SNAT9; SLC38A10; SNAT10; SLC38A11; SNAT11; SLC; SLC38; SNATs; SNAT; RT-qPCR; GABA; glutamine; glutamate;

   Sammanfattning : Solute carriers consist of over 400 genes and 66 subfamilies and are the largest group of membrane bound transporters. They facilitate movement of many molecules through cells and organelles and are crucial for upholding many key functions in the human body. They are also involved in the pathophysiology of several diseases. LÄS MER

3. 2. In silico and in vitro determination of substrate specificity for Breast Cancer Resistance Protein (BCRP) transporter at the blood-brain barrier

   Master-uppsats, Uppsala universitet/Institutionen för farmaci

   Författare :Fen Wang; [2021]
   Nyckelord :BCRP; substrate specificity; BBB; ATP-binding cassette ABC transporter; Drug transport;

   Sammanfattning : Background The Breast Cancer Resistance Protein (BCRP) drug transporter is important for drug disposition and plays a critical role in regulating drug entry into the brain. Its substrate spectrum overlaps with substrates of Multi Drug Resistance Protein 1 (MDR1, P-gp), which influences and complicates the interpretation of data on drug distribution into tissues (e. LÄS MER

4. 3. Models for predicting efflux transport over the blood-brain barrier

   Master-uppsats, Uppsala universitet/Institutionen för farmaci

   Författare :Marjaneh Janani; [2020]
   Nyckelord :efflux transport; brain; blood-brain-barrier; Verapamil; Risperidone; Prazosin;

   Sammanfattning : Aim: The general aim of this research is development and evaluation of novel methods for predicting active transport over the human blood-brain-barrier (BBB), while this project specifically aims to i) review the literature and select suitable methods and substrates, ii) develop models for determining in vitro kinetic properties of selected compounds, analyze the in vitro data using the developed models and to use Maximum Transport Activity (MTA) approach (Karlgren et al., 2012), iii) perform Physiology Based Pharmacokinetic (PBPK) modelling and compare to in vivo literature data. LÄS MER

5. 4. Models for predicting efflux transport over the blood-brain barrier

   Master-uppsats, Uppsala universitet/Institutionen för farmaceutisk biovetenskap

   Författare :Marjaneh Janani; [2020]
   Nyckelord :Efflux; blood-brain-barrier; modeling; transporter;

   Sammanfattning : Aim: The general aim of this research is development and evaluation of novel methods for predicting active transport over the human blood-brain-barrier (BBB), while this project specifically aims to i) review the literature and select suitable methods and substrates, ii) develop models for determining in vitro kinetic properties of selected compounds, analyze the in vitro data using the developed models and to use Maximum Transport Activity (MTA) approach (Karlgren et al., 2012), iii) perform Physiology Based Pharmacokinetic (PBPK) modelling and compare to in vivo literature data. LÄS MER

7. 5. MDR1-mutationen hos hundar

   Kandidat-uppsats, SLU/Dept. of Biomedical Sciences and Veterinary Public Health

   Författare :Johanna Olsson; [2015]
   Nyckelord :P-glykoprotein; MDR1; mutation; hund; makrocykliska laktoner; P-glycoprotein; dog; macrocyclic lactones;

   Sammanfattning : P-glykoprotein (P-gp) är en effluxtransportör som ursprungligen uppmärksammades för sin kapacitet att skydda tumörceller från flertalet läkemedel. Det har sedan visat sig att P-gp även finns i andra vävnader, som tarm, njurtubuli, lever samt i hjärnans kapillära endotelceller. LÄS MER