Sökning: "embryonic stem cells"

Visar resultat 6 - 10 av 22 uppsatser innehållade orden embryonic stem cells.

1. 6. Transcriptional changes in stem cell-derived cardiomyocytes during extended cell cultures

   Kandidat-uppsats, Högskolan i Skövde/Institutionen för biovetenskap

   Författare :Michel Jonathan Speh; [2020]
   Nyckelord :;

   Sammanfattning : The recent advancement in the field of stem cell research gave rise to high expectations from both general and scientific audiences, and indeed, stem cells and stem cell-derived cells have an enormous potential to forward the fields of medical research and regenerative medicine. Nevertheless, there are still many obstacles and limitations associated with stem cell technology. LÄS MER

3. 7. Patterning of the neural tube: A 3D computational modelling approach

   Master-uppsats, Lunds universitet/Institutionen för astronomi och teoretisk fysik - Genomgår omorganisation; Lunds universitet/Beräkningsbiologi och biologisk fysik - Genomgår omorganisation

   Författare :Ariane Ernst; [2019]
   Nyckelord :gene regulatory networks; neural tube patterning; patterning of the neural tube; dopaminergic neurons; parkinson s disease; computational modelling; stem cell; GRN; Biology and Life Sciences; Physics and Astronomy;

   Sammanfattning : Neurodegenerative diseases such as Parkinson’s can be treated with stem-cell derived specialized neurons. In order to achieve precise directed neural differentiation in vitro we need to understand the gene regulatory mechanisms behind in vivo neural tube patterning. LÄS MER

4. 8. Sex differences in neuronal differentiation of human stem cells

   Master-uppsats, Uppsala universitet/Institutionen för biologisk grundutbildning

   Författare :Olga Doszyn; [2019]
   Nyckelord :stem cells; neural stem cells; embryonic stem cells; sex differences; neuronal differentiation;

   Sammanfattning : Sexual dimorphism has been long noted in human neurobiology, apparent most notably in sex-biased distribution of multiple neurological disorders or diseases, from autism spectrum disorder to Parkinson's disease. With the advances in molecular biology, genetics and epigenetics have come into focus as key players in sexually dimorphic neural development; and yet, many studies in the field of neuroscience overlook the importance of sex for the human brain. LÄS MER

5. 9. Identifying Cell Reprogramming Roadblocks by Modelling Induced Pluripotency with Boolean Networks and Dynamical Systems

   Master-uppsats, Lunds universitet/Institutionen för astronomi och teoretisk fysik - Genomgår omorganisation; Lunds universitet/Beräkningsbiologi och biologisk fysik - Genomgår omorganisation

   Författare :Johannes Isaksson; [2018]
   Nyckelord :Stem cells; pluripotency; pluripotent; reprogramming; iPS; induced pluripotency; Boolean; dynamical systems; network.; Medicine and Health Sciences;

   Sammanfattning : The generation of induced pluripotent stem (iPS) cells from differentiated cells is a process of great scientific interest due to the medical potential of such cells. This process (called 'reprogramming' of cells) is however notoriously inefficient and still not very well understood. LÄS MER

7. 10. CRISPR/Cas9 gene-editing in an in vitro model of a familial form of ALS

   Master-uppsats, Lunds universitet/Tillämpad biokemi; Lunds universitet/Beräkningskemi

   Författare :Fredrik Nilsson; [2018]
   Nyckelord :ALS; SOD1; Amyotrophic lateral sclerosis; superoxide dismutase; CRISPR Cas9; sgRNA; stem cell; lentivirus; qPCR; FOXG1; nestin; immunocytochemistry; differentiation; forebrain neural progenitor; Applied Biochemistry; Biology and Life Sciences;

   Sammanfattning : Amyotrophic lateral sclerosis (ALS) is a neuromuscular disease characterized by the degeneration and death of both upper and lower motor neurons for which there is no cure currently available. The degeneration of motor neurons leads to the inability to carry out voluntary movement and death usually occurs 3-5 years after disease onset by respiratory failure. LÄS MER