Sökning: "experimental mouse model"

Visar resultat 1 - 5 av 8 uppsatser innehållade orden experimental mouse model.

  1. 1. Sex-specific pathological response to Traumatic Brain Injury

    Master-uppsats, Lunds universitet/Examensarbeten i molekylärbiologi

    Författare :Christopher Fry; [2022]
    Nyckelord :Biology and Life Sciences;

    Sammanfattning : Traumatic brain injury (TBI) is one of leading causes of death in the world; survivors commonly exhibit behavioural changes and neurocognitive defects in the long-term. Following TBI, rapid changes in the neurovascular unit (NVU) occur as the permeability of the blood brain barrier (BBB) increases and cerebral blood flow (CBF) becomes dysregulated. LÄS MER

  3. 2. Whole-Cell Patch Clamp Investigations on Rapid Synaptic Scaling of Mouse CA1 Pyramidal Neurons under Optogenetic Stimulation

    Master-uppsats, Lunds universitet/Tillämpad biokemi; Lunds universitet/Beräkningskemi

    Författare :Leonard Groth; [2021]
    Nyckelord :Patch clamp; Electrophysiology; Optogenetics; Epilepsy; Voltage clamp; Current clamp; Neuroscience; Applied Biochemistry; Tillämpad biokemi; Technology and Engineering;

    Sammanfattning : The brain consists of billions of neurons forming intricate contiguous networks. The connective strength in these networks change throughout life in response to experience and environmental stimuli. LÄS MER

  4. 3. Effects of Different Laminins on Human Neural Progenitor Cells Cultured in 3D Electrospun Fibers

    Master-uppsats, Lunds universitet/Tillämpad biokemi; Lunds universitet/Beräkningskemi

    Författare :Karl Vesterlund; [2019]
    Nyckelord :two-dimensional; three-dimensional; Alamar Blue; cell culture; drug development; extra-cellular matrix; electrospinning; immunocytochemistry; laminin; polycaprolactone; polymerase chain reaction; western blot; applied biochemistry; tillämpad biokemi; Technology and Engineering; Biology and Life Sciences;

    Sammanfattning : A low success rate of drug candidates in clinical trials, and especially in brain research, motivates development of better screening models. Hence, in neuroscience and many other fields of Life Science, development of more physiological relevant experimental cell-based models is motivated. LÄS MER

  5. 4. Assessing the ability of LARGE overexpression to prevent the development of muscular dystrophy

    Master-uppsats, SLU/Dept. of Biomedical Sciences and Veterinary Public Health

    Författare :Astrid Rudberg; [2014]
    Nyckelord :duchenne muscular dystrophy; muscular dystrophy; prevention; LARGE; mdx; mouse model; duchenne muskulär dystrofi; förhindra; musmodell;

    Sammanfattning : Duchenne Muscular Dystrophy (DMD) is a hereditary X-linked fatal disease that affects 1 in 3500 male births. It is the most common kind of muscular dystrophy in children and leads to death in the late teens or early 20s for many patients. The mdx mouse is a model of DMD that can be used to investigate experimental therapies. LÄS MER

  7. 5. Differential and co-expression of long non-coding RNAs in abdominal aortic aneurysm

    Uppsats för yrkesexamina på avancerad nivå, Uppsala universitet/Institutionen för biologisk grundutbildning

    Författare :Joakim Karlsson; [2014]
    Nyckelord :lncRNA; lincRNA; abdominal aortic aneurysm; differential expression; co-expression; RNA-seq; WGCNA;

    Sammanfattning : This project concerns an exploration of the presence and interactions of long non-coding RNA transcripts in an experimental atherosclerosis mouse model with relevance for human abdominal aortic aneurysm development. 187 long noncoding RNAs, two of them entirely novel, were found to be differentially expressed between angiotensin II treated (developing abdominal aortic aneurysms) and non-treated apolipoprotein E deficient mice (not developing aneurysms) harvested after the same period of time. LÄS MER