Sökning: "fibrillation kinetics"

Hittade 3 uppsatser innehållade orden fibrillation kinetics.

  1. 1. Fluorescent fusion proteins as probes to characterize tau fibril polymorphism

    Master-uppsats, Linköpings universitet/Kemi

    Författare :Max Lindberg; [2019]
    Nyckelord :Alzheimer’s disease AD ; amyloids; FRET; tau; MAPT; fibrillation kinetics; seeding; fusion protein; EGFP; ECFP; EYFP; ThT; X-34; BTD14;

    Sammanfattning : Alzheimer's disease (AD) is a large and growing problem and while we today lack a full understanding of this disease, we know that the protein tau and the amyloid fibrils it forms play a central role in its development. We also know that these fibrils can have different morphologies in different diseases and that fibrils produced in vitro not necessarily adopt any of the morphologies found in patients. LÄS MER

  3. 2. Studies of Aβ aggregation, toxicity and cellular uptake

    Kandidat-uppsats, SLU/Dept. of Anatomy, Physiology and Biochemistry

    Författare :Chiara Beretta; [2016]
    Nyckelord :Alzheimer’s disease; amyloid-beta; fluorescence; cellular uptake; labeling;

    Sammanfattning : Alzheimer’s disease (AD) is the most common type of dementia observed in the elderly. The symptoms of the disease are provoked by neuronal loss caused by neurofibrillary tangles and amyloid plaques. The molecular processes that underlie AD’s pathology are at this day not well understood. LÄS MER

  4. 3. Kinetic and Surface Properties of alpha-synuclein : Investigating the Difference between Pure Peptide and Phospholipid Including Aggregates

    Master-uppsats, Lunds universitet/Kemiska institutionen

    Författare :Irem Nasir; [2011]
    Nyckelord :Nanokemi; Chemistry;

    Sammanfattning : Popular summary Parkinson's Disease is a disorder caused by brain that affects patients' coordination, movement as well as causing tremor. The onset of Parkinson's Disease is found to be the large fibrillar aggregates in the brain which consists mostly alpha-synuclein protein. LÄS MER