Sökning: "first in vivo pharmacokinetic experiment"

Hittade 2 uppsatser innehållade orden first in vivo pharmacokinetic experiment.

1. 1. Optimized design recommendation for first pharmacokinetic in vivo experiments for new tuberculosis drugs using pharmacometrics modelling and simulation

   Uppsats för yrkesexamina på avancerad nivå, Uppsala universitet/Institutionen för farmaci

   Författare :Albin Leding; [2021]
   Nyckelord :Pharmacokinetics; Pharmacometrics; Pharmacology; population pharmacokinetics; physiologically-based pharmacokinetics; in vitro to in vivo extrapolation; IVIVE; PBPK; PK; popPK; tuberculosis; model informed approach; first in vivo pharmacokinetic experiment; mouse; mice; PKSim; NONMEM; in vitro; in vivo;

   Sammanfattning : Tuberculosis, the leading cause of death by a single infection disease caused by bacteria, requires long treatments and the bacteria are prone to develop drug resistance. Therefore, new efficient treatment regiments needs developing, which requires new tools for drug development. LÄS MER

3. 2. Characterization of the effect of the membrane on in vitro dissolution profiles for pulmonary drug delivery

   Uppsats för yrkesexamina på avancerad nivå, Uppsala universitet/Institutionen för farmaci

   Författare :Maral Simonides; [2021]
   Nyckelord :Oral inhalation; in vitro dissolution; Budesonide; Fluticasone propionate; Transwell;

   Sammanfattning : It has always been a challenge to imitate the lung environment, therefore there is a constant development of standardized in vitro dissolution methods for inhaled products. Dissolution in vitro has been considered as an important parameter, because low solubility determines the bioavailability of inhaled drugs. LÄS MER