Sökning: "fluorimetry"

Visar resultat 1 - 5 av 10 uppsatser innehållade ordet fluorimetry.

  1. 1. Structural and Functional Characterisation of the Human Mitochondrial Pyruvate Carrier

    Master-uppsats, Lunds universitet/Kemiska institutionen

    Författare :Simon Gripvall; [2023]
    Nyckelord :biochemistry; complex; MPC; proteoliposomes; pyruvate; transport; Chemistry;

    Sammanfattning : The metabolism of pyruvate in the cell is abnormally regulated in several human diseases, such as type-II diabetes, cancer and neurodegenerative disorders, in which the human mitochondrial pyruvate carrier (HuMPC) sits at a pivotal point. It transports pyruvate across the inner mitochondrial membrane and consists of two proteins, MPC1 and MPC2, and is a potential drug target against these diseases. LÄS MER

  3. 2. Acquired and lost structure-functions of non-enveloped and enveloped viruses

    Master-uppsats, Uppsala universitet/Institutionen för biologisk grundutbildning

    Författare :Diogo Filipe; [2022]
    Nyckelord :;

    Sammanfattning : Viruses are biological entities that constantly affect the world around us and in many cases they can harm the health of humans and negatively impact food production, in agriculture andfisheries. The project concept is that, through the structural studies of viruses that infectsimple hosts, it is possible to point out structural features that are unique and conserved inviruses, that infect human, other animals, and crops, in the same phylogenetic lineage. LÄS MER

  4. 3. Structural features underlying antigen presentation by the non-classical MHC class Ib molecule Qa-1b

    Master-uppsats, KTH/Proteinvetenskap

    Författare :Lejla AI-Tamimi; [2022]
    Nyckelord :immune checkpoint; NKG2A; MHC class Ib; Qdm; antibody; crystal structure;

    Sammanfattning : Blockering av NKG2A receptorn på NK - och CD8+ T celler med en anti-NKG2A antikropp, medför en aktivering av cytolytisk aktivitet, och är en lovande immunkontrollpunkt i immunterapi mot cancer. Nyligen har en TCR-liknande antikropp, EXX1, som binder till liganden för NKG2A receptorn, Qa-1b - en icke-klassisk MHC klass Ib molekyl i möss -studerats i tumör modeller in vitro. LÄS MER

  5. 4. Investigation of the function of the SH3-like domain of the Saccharopolyspora erythraea iron-dependent regulator

    Master-uppsats, Uppsala universitet/Institutionen för kemi - BMC

    Författare :Carita Hammar; [2022]
    Nyckelord :;

    Sammanfattning : The bacterium Saccharopolyspora erythraea is utilized to produce the widely used antibiotic erythromycin. With the increasing problem of antibiotic resistance, the development of derivatives of the drug is of great importance. To produce antibiotics biosynthetically, it is crucial to understand the metabolic pathways utilized by the bacterium. LÄS MER

  7. 5. Biophysical characterization of and screening for binders and potentiator compounds that modulate the binding of PDZ domains to the C-terminal peptide motifs of target proteins

    Master-uppsats, KTH/Proteinvetenskap

    Författare :Carl Olsson; [2021]
    Nyckelord :Post synaptic density protein 95; PDZ-domains; N-methyl-D-aspartate receptor; NMDAR hypofunctional hypothesis; GluN2b; Differential scanning fluorimetry; Surface plasmon resonance; Fragment based drug design; Assay development;

    Sammanfattning : The N-methyl-D-aspartate receptor (NMDAR) hypofunctional hypothesis is believed to explain one of the contributing factors to schizophrenia. This hypothesis suggests the dysregulation of NMDAR, a protein responsible for receiving signals from the synapses between neurons, is the cause of some of the symptoms seen in schizophrenia. LÄS MER