Sökning: "helical"

Visar resultat 6 - 10 av 48 uppsatser innehållade ordet helical.

  1. 6. Surface Guided Helical Tomotherapy for Total Marrow Irradiation

    Master-uppsats, Lunds universitet/Sjukhusfysikerutbildningen

    Författare :Hedda Enocson; [2022]
    Nyckelord :Medicine and Health Sciences;

    Sammanfattning : Background: Total marrow irradiation (TMI) with helical tomotherapy treatment (HT-TMI) can be used as conditioning regimen for leukemia patients prior to stem cell transplantation by radiating the skeletal tissue. To ensure adequate dose coverage a margin is applied to the clinical target volume (CTV), i.e. planning target volume (PTV) margin. LÄS MER

  3. 7. Optimization of immunotherapeutic relevant ABD-derived affinity proteins for prolonged serum half-life

    Master-uppsats, KTH/Proteinvetenskap

    Författare :Ebba Bergström; [2022]
    Nyckelord :Half-Life extension; Human serum Albumin HSA ; Interleukin 17c IL17c ; ABD-Derived Affinity ProTeins ADAPT ; Protein-based drugs.;

    Sammanfattning : Marknaden för proteinbaserade läkemedel, de så kallade biologiska läkemedlen, är idag en industri som omsätter miljarder. Ett vanligt sätt att utveckla dessa läkemedel på är med hjälp av monoklonala antikroppar då de kan binda till sitt mål med hög specificitet. LÄS MER

  4. 8. Towards an understanding of the Retraction of TYPE IV PILI as a Mechanoresponse upon surface contact in Pseudomonas Aeruginosa

    Master-uppsats, KTH/Skolan för kemi, bioteknologi och hälsa (CBH)

    Författare :Antoine Loussouarn; [2022]
    Nyckelord :Mechanosensing; Microscopy; Bacteria; Microfabrication; Genetics; Molecular Biology; Biophysics;

    Sammanfattning : Pseudomonas Aeruginosa is an opportunistic bacterium which is involved in nosocomial infections and which causes increasing concern in healthcare due to its high antibiotic resistance. During an infection by P.aeruginosa, the bacteria proliferate in the host’s organism by leveraging motility abilities. LÄS MER

  5. 9. Investigation of the function of the SH3-like domain of the Saccharopolyspora erythraea iron-dependent regulator

    Master-uppsats, Uppsala universitet/Institutionen för kemi - BMC

    Författare :Carita Hammar; [2022]
    Nyckelord :;

    Sammanfattning : The bacterium Saccharopolyspora erythraea is utilized to produce the widely used antibiotic erythromycin. With the increasing problem of antibiotic resistance, the development of derivatives of the drug is of great importance. To produce antibiotics biosynthetically, it is crucial to understand the metabolic pathways utilized by the bacterium. LÄS MER

  7. 10. Characterization of novel ZCa-based variants to investigate calcium dependent target interaction

    Master-uppsats, KTH/Proteinvetenskap

    Författare :Gabriella Rossi; [2021]
    Nyckelord :ZCa; IgE; IL-23; recycling antibody; calcium-dependency;

    Sammanfattning : ZCa is an engineered three-helical affinity protein that through replacement of the loop between helix two and three with an EF-hand motif has a calcium-dependent binding to its target. By using the difference of calcium concentration in the plasma and the cell along with the favorable properties of ZCa, the interest in creating therapeutics toward different diseases based on the ZCa scaffold has come about. LÄS MER