Sökning: "heparan sulfate"

Visar resultat 1 - 5 av 6 uppsatser innehållade orden heparan sulfate.

  1. 1. The roles of heparan sulfate in autophagy

    Master-uppsats, Uppsala universitet/Institutionen för medicinsk biokemi och mikrobiologi

    Författare :Asifa Khan; [2022]
    Nyckelord :Heparan sulfate; LC3-II; p62; Autophagy;

    Sammanfattning : Background: Autophagy is a lysosomal degradation process to eliminate damaged components from the cells. It also provides a survival mechanism in stressed conditions and limits growth processes. Heparan sulfate (HS) is a polysaccharide attached to different proteoglycans. LÄS MER

  3. 2. Gene expression analysis of fibroblast growth factor in a rat model of human endometrial cancer

    Magister-uppsats, Högskolan i Skövde/Institutionen för biovetenskap

    Författare :Vipul Chakole; [2018]
    Nyckelord :;

    Sammanfattning : The fibroblast growth factor receptor (FGF/FGFR) signaling has a significant role in normal organ development, like vascular and skeletal development. The dysregulation of the fibroblast growth receptor signaling occursdue to genetic modification or over expression of the receptor. This has been observed in different carcinomas [34,35]. LÄS MER

  4. 3. Expression of the heparan sulfate biosynthesis enzymes NDST1 and NDST2 and their major splice variants in human tissues.

    L3-uppsats, Uppsala universitet/Institutionen för medicinsk biokemi och mikrobiologi

    Författare :Fredrik Kristoffersson; [2018]
    Nyckelord :Heparan sulfate; NDST; glycobiology; N-Deacetylase And N-Sulfotransferase; NGS; bioinformatics;

    Sammanfattning : The aim of the study was to investigate the expression NDST transcripts in a wide variety of tissues using RNA-sequencing experimental data from five published studies, using two common in silico tools: the Tophat-Cufflink pipeline and the HTSeq-DEXSeq pipeline. We show that to detect NDST alternative transcripts, paired-end sequencing should be used with replicates of samples or conditions together with 100 base read length to allow for reliable detection of the low expressed transcripts in the NDST family. LÄS MER

  5. 4. Investigation of Syndecan-1 Ectodomain Isolated from Chinese Hamster Ovary (CHO) Cell Culture Medium

    Kandidat-uppsats, Uppsala universitet/Institutionen för medicinsk biokemi och mikrobiologi; Uppsala universitet/Obstetrik & gynekologi

    Författare :Daniel Croce; [2015]
    Nyckelord :proteoglycan; heparan sulfate; glycosaminoglycan; chondroitin sulfate; shedding;

    Sammanfattning : Syndecan-1 is a cell surface proteoglycan which participates in cell adhesion, differentiation, motility, morphogenesis and intracellular signaling. The two glycosaminoglycans heparan sulfate and chondroitin sulfate are covalently attached to the ectodomain of syndecan-1 via a tetra saccharide linkage sequence. LÄS MER

  7. 5. Synthesis towards an aromatic alfa-dixyloside

    Master-uppsats, Lunds universitet/Centrum för analys och syntes

    Författare :Martin Olofsson; [2015]
    Nyckelord :Synthesis; Proteoglycan; Glucosaminoglycan; Xylose; Carbohydrate; Glycosylation; Organic chemistry; Chemistry;

    Sammanfattning : A proteoglycan is a protein with at least one glycosidic chain or glycosaminoglycan (GAG) covalently bound to it. Since a common linker between the core protein and the GAG chain has a xylose present, the biosynthesis of GAGs can be primed using xylosides containing hydrophobic aglycons providing that these xylosides are capable of penetrating the cell membrane. LÄS MER