Sökning: "huntingtin lowering"

Hittade 1 uppsats innehållade orden huntingtin lowering.

  1. 1. Huntingtin gene profiling, towards allele-specific treatment

    Master-uppsats, KTH/Skolan för kemi, bioteknologi och hälsa (CBH)

    Författare :Mimmi Håkansson; [2020]
    Nyckelord :Huntington’s disease; huntingtin lowering; allele-selective; HD animal models; Huntingtons sjukdom; huntingtin sänkning; allel-specifik; Huntington djurmodeller;

    Sammanfattning : Huntington diseases(HD) is a fatal autosomal neurodegenerative genetic disorder, caused by a CAG trinucleotide repeat expansion in the huntingtin (HTT) gene, resulting in a toxic gain-of-function in the mutant huntingtin protein(mHTT). To date, there is no approved treatment to either cure or halt the course of HD. LÄS MER