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Visar resultat 1 - 5 av 37 uppsatser som matchar ovanstående sökkriterier.

1. 1. Vaccine development during a pandemic : A case study of an academic research group in Sweden and their vaccine(s) against SARS-CoV-2

   Master-uppsats, Uppsala universitet/Institutionen för kulturantropologi och etnologi

   Författare :Anna Tarnovskaya; [2023]
   Nyckelord :vaccine development; COVID-19; discursive practices; situational analysis; grounded theory; DNA vaccine;

   Sammanfattning : This ethnographic study examines the multiple ways in which a vaccine against SARS-CoV-2 disease and infection is known in an academic research group in Sweden. This academic research group has been working to develop a vaccine since the start of the COVID-19 pandemic in early 2020. LÄS MER

3. 2. Predicting tumour growth-driving interactions from transcriptomic data using machine learning

   Uppsats för yrkesexamina på avancerad nivå, Uppsala universitet/Neuroonkologi och neurodegeneration

   Författare :Mathilda Stigenberg; [2023]
   Nyckelord :cancer; immunology; cell-cell interactions; deep learning; variational autoencoder; supervised variational autoencoder; tumour microenvironment; single-cell RNA sequencing; spatial transcriptomics; breast cancer; machine learning;

   Sammanfattning : The mortality rate is high for cancer patients and treatments are only efficient in a fraction of patients. To be able to cure more patients, new treatments need to be invented. Immunotherapy activates the immune system to fight against cancer and one treatment targets immune checkpoints. LÄS MER

4. 3. Exploratory analysis of immunological responses in wild and laboratory mice

   Kandidat-uppsats, Högskolan i Skövde/Institutionen för biovetenskap

   Författare :Ilia Alekseev; [2023]
   Nyckelord :;

   Sammanfattning : The use of mice as a model organism in biomedical research is widespread due to their similarities with humans in anatomy and physiology. However, the genetic isolation of inbred strains from natural populations raises concerns about the reliability of these models. LÄS MER

5. 4. Single-cell RNA-seq mapping of chicken leukocytes : An investigation into single-cell transcriptomics as an alternative to traditional immunological methods within non-traditional model organisms

   Uppsats för yrkesexamina på avancerad nivå, Uppsala universitet/Mikrobiologi och immunologi

   Författare :Matilda Maxwell; [2023]
   Nyckelord :Bioinformatics; scRNA-seq; avian; immunology; Seurat; leukocytes; chicken; gallus gallus; 10x genomics; PCA;

   Sammanfattning : The immune system is a complex infrastructure where many cells interact with each other and perform duties depending on their type and function. When using traditional immunological methods in studying non-traditional model organisms, such as birds, challenges arise. LÄS MER

7. 5. Molecular mapping of the HGSOC tumour microenvironment

   Master-uppsats, Uppsala universitet/Institutionen för medicinsk biokemi och mikrobiologi

   Författare :Philippine Louail; [2023]
   Nyckelord :Immunology; Ovarian cancer; Multiplex Immunofluorescence; scRNA sequencing; Bioinformatics; Image analysis;

   Sammanfattning : High-grade serous ovarian cancer (HGSOC) is the most aggressive subtype of ovarian cancer, and its heterogeneity poses a challenge for the discovery of reliable diagnostic biomarkers, therapeutic targets, and predicting treatment response, particularly to immunotherapy. The current standard diagnostic and treatment options are inadequate, resulting in late diagnosis and poor prognosis. LÄS MER